Detailed information of TA system TA125802

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 107550..109133
• Replicon: chromosome
• Accession: NZ_CP040440
• Organism: Stenotrophomonas maltophilia strain ICU331

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: B2FHA0
• Locus tag: FEO84_RS00445
• Protein ID: WP_012478717.1
• Coordinates: 107550..108872 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: FEO84_RS00450
• Protein ID: WP_005407534.1
• Coordinates: 108876..109133 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEO84_RS00430	102945..104579	-	1635	WP_005407530.1	TldD/PmbA family protein	-
FEO84_RS00435	104610..106241	-	1632	WP_049395460.1	TldD/PmbA family protein	-
FEO84_RS00440	106935..107549	+	615	WP_049397989.1	DUF938 domain-containing protein	-
FEO84_RS00445	107550..108872	-	1323	WP_012478717.1	type II toxin-antitoxin system HipA family toxin	Toxin
FEO84_RS00450	108876..109133	-	258	WP_005407534.1	helix-turn-helix transcriptional regulator	Antitoxin
FEO84_RS00455	109295..112981	-	3687	WP_049397988.1	indolepyruvate ferredoxin oxidoreductase family protein	-
FEO84_RS00460	113153..113788	+	636	WP_005407536.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (19-70)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49058.99 Da
• Isoelectric Point: 7.0868

>T125802 WP_012478717.1 NZ_CP040440:c108872-107550 [Stenotrophomonas maltophilia]
MGTLQVWMNGVEVALWDDVRNGSSRLSYVSQWISSPQSRPLSLSLPLLPDGESHRGNVVNDYFDNLLPDNVAIRNRIRDR
FATRGSDTFDLLEAIGRDCVGAVQLLPPARPPEDIQQITCEVLDEAGVATILRQVTTGNLPGAPSRDDAFRISIAGAQEK
TGLLLHAGKWCIPTGNTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMHLLSAFDIPVAETQMGRFNDQRALIVERFDRR
LSADRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVPIMDLLRQSEHPEDRAIFFKTQILFWMLAATDGHAKNFSVHLE
AGGRFRLTPVYDVLSVYPILGRGPNQLDPRNAQLAMAVHGKNRHRKLHLVRRRHWNETARACGVADGAEPWIKTLIAAVE
PAIQQVTRQLPDDFPSNVSEPIFNGLRAAAARLSSMAPEA

Nucleotide

• Length: 1323 bp

>T125802 NZ_CP040440:c108872-107550 [Stenotrophomonas maltophilia]
ATGGGTACGCTGCAGGTCTGGATGAATGGTGTGGAAGTCGCACTTTGGGATGATGTCCGGAACGGGTCATCCCGGTTGTC
GTATGTCAGCCAGTGGATCAGCTCGCCCCAGTCCCGACCGTTGTCGCTCTCTCTACCCCTGCTCCCAGATGGCGAGAGCC
ATCGGGGCAACGTCGTCAACGACTACTTCGATAACCTTCTTCCCGATAACGTCGCCATACGCAACCGGATCCGCGACCGG
TTCGCCACGCGCGGCAGCGATACGTTCGATCTTCTTGAAGCCATTGGACGGGATTGTGTCGGCGCAGTGCAGCTGTTGCC
GCCAGCGCGTCCACCCGAAGACATCCAGCAGATCACGTGCGAGGTGTTGGACGAAGCAGGTGTCGCTACGATCCTGCGTC
AGGTGACGACAGGGAACCTGCCTGGCGCACCCAGCCGTGATGATGCATTCCGCATTTCCATCGCCGGTGCGCAGGAAAAG
ACCGGTCTTCTGCTGCATGCTGGCAAATGGTGCATTCCTACCGGCAACACACCATCCACTCACATCTTCAAGCTGCCGCT
TGGCATTGTTGGCAACATGCGGGCAGACATGCATCAGTCCGTGGAGAATGAATGGCTGTGCATGCATCTGCTTTCCGCCT
TTGATATCCCCGTGGCCGAGACGCAGATGGGCCGCTTCAACGACCAACGTGCTCTCATTGTCGAGCGGTTTGACCGTCGC
CTGTCTGCCGACCGCCGGTGGTGGCTGCGACTGCCACAGGAAGACATGTGTCAGGTCTTTGGTCTGCCGGCTGCCAGAAA
GTATGAATCCGATGGCGGCCCCGGTATCGTTCCGATCATGGATCTGCTTCGACAGTCCGAACACCCCGAGGATCGCGCGA
TCTTCTTCAAGACGCAGATTCTTTTCTGGATGCTGGCCGCAACCGACGGCCATGCCAAGAATTTCAGTGTTCACCTGGAA
GCCGGTGGACGCTTCCGCCTGACGCCCGTCTACGACGTGCTGTCGGTATATCCCATCCTCGGCAGGGGACCCAATCAACT
CGATCCACGAAACGCACAGCTCGCCATGGCCGTACATGGCAAGAACCGCCACCGGAAACTGCACCTTGTGCGACGGCGGC
ACTGGAATGAAACCGCGCGCGCCTGCGGCGTTGCCGATGGTGCAGAACCATGGATCAAGACATTGATCGCGGCCGTCGAG
CCCGCCATCCAGCAGGTCACCCGTCAGCTCCCGGATGACTTCCCCTCAAACGTGTCCGAACCGATTTTCAACGGACTTCG
TGCTGCGGCAGCACGCCTTTCCAGCATGGCCCCCGAGGCTTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9584.97 Da
• Isoelectric Point: 11.8468

>AT125802 WP_005407534.1 NZ_CP040440:c109133-108876 [Stenotrophomonas maltophilia]
MDRPLHTVRTAQQLAPLMRAFRRQAGLSQAQLAERLGISRQAVGALERDPASASFERLMRIWAVLGLEVSLQQRSPQENT
SSLEW

Nucleotide

• Length: 258 bp

>AT125802 NZ_CP040440:c109133-108876 [Stenotrophomonas maltophilia]
ATGGACAGGCCGCTGCACACAGTGAGGACAGCCCAACAACTTGCGCCCCTGATGCGTGCTTTCCGGCGCCAGGCGGGCCT
GAGCCAGGCTCAGCTGGCGGAGCGACTCGGGATCAGCCGCCAGGCAGTGGGCGCGCTGGAACGCGACCCTGCATCGGCAA
GTTTTGAACGCCTGATGCGGATCTGGGCGGTGCTGGGTCTGGAGGTCAGCCTCCAGCAACGAAGTCCCCAGGAGAACACG
TCGTCATTGGAGTGGTGA

Structures

Toxin

• AlphaFold DB: A0A7G7P5V7