Detailed information of TA system TA125801

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-dnstrm_HI1420
• Location: 259141..259789
• Replicon: chromosome
• Accession: NZ_CP040439
• Organism: Stenotrophomonas maltophilia strain PEG-141

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: A0A0L8AET4
• Locus tag: FEO88_RS01140
• Protein ID: WP_010486984.1
• Coordinates: 259141..259428 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: FEO88_RS01145
• Protein ID: WP_049431463.1
• Coordinates: 259487..259789 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEO88_RS01110	254365..255096	+	732	WP_005407698.1	type III pantothenate kinase	-
FEO88_RS01115	255106..255942	+	837	WP_154351904.1	SPOR domain-containing protein	-
FEO88_RS01125	256188..257039	-	852	WP_154351905.1	hypothetical protein	-
FEO88_RS01130	257161..258285	-	1125	WP_154351906.1	hypothetical protein	-
FEO88_RS01135	258308..258907	-	600	WP_154351907.1	hypothetical protein	-
FEO88_RS01140	259141..259428	+	288	WP_010486984.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FEO88_RS01145	259487..259789	+	303	WP_049431463.1	putative addiction module antidote protein	Antitoxin
FEO88_RS01150	259847..260170	-	324	WP_154351908.1	hypothetical protein	-
FEO88_RS01155	260251..260658	-	408	WP_149909334.1	hypothetical protein	-
FEO88_RS01160	261240..262184	+	945	WP_154351909.1	ankyrin repeat domain-containing protein	-
FEO88_RS01165	262202..262549	-	348	WP_049421445.1	hypothetical protein	-
FEO88_RS01170	262682..263602	+	921	WP_154261980.1	arginase	-
FEO88_RS01175	263764..263901	+	138	WP_154351910.1	entericidin A/B family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	256188..265249	9061

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-90)

Antitoxin

• Uncharacterized protein HI1420 (6-99)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10744.34 Da
• Isoelectric Point: 10.8940

>T125801 WP_010486984.1 NZ_CP040439:259141-259428 [Stenotrophomonas maltophilia]
MKIQRTRQFATWIDALKDVTARARILARIGRLAEGHPGDHRYLADGVSELRIDAGPGYRVYYTQRGRQLVILLVGGDKGS
QQRDIEKAREIARAL

Nucleotide

• Length: 288 bp

>T125801 NZ_CP040439:259141-259428 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCCGGAGATCACCGCTATCTGGCGGATGGCGTTTCTGAATTGCGTATCGATG
CAGGACCGGGTTACCGCGTGTACTACACCCAGCGCGGCAGGCAGTTGGTGATTCTCCTGGTTGGAGGCGACAAGGGTTCA
CAGCAGCGCGATATCGAGAAGGCCAGGGAGATTGCGCGTGCCCTGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10778.38 Da
• Isoelectric Point: 8.0359

>AT125801 WP_049431463.1 NZ_CP040439:259487-259789 [Stenotrophomonas maltophilia]
MAIKRKVELKSFDVAEHLRTPEEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPD
FATILKVTRALGVRLHASAV

Nucleotide

• Length: 303 bp

>AT125801 NZ_CP040439:259487-259789 [Stenotrophomonas maltophilia]
ATGGCCATCAAGAGAAAAGTTGAACTCAAATCATTTGATGTGGCCGAGCATCTTCGGACGCCGGAGGAGATGGCGGCTTA
TCTCGACGCCTGCATCGAAGAAAGCGACGGTGATTCTGCATTTATCGCCAAGGCGCTCGGCGATATCGCTCGCGCTCAGG
GCATGAGCAAGGTTGCGCGTGCGGCGGGCTTGTCGCGTGAGAGTCTGTATCGCGCACTGTCGGGTGAGCGCAGCCCGGAT
TTCGCGACCATCCTGAAGGTGACCCGGGCCCTGGGTGTGCGATTGCACGCCAGCGCTGTGTAA

Structures

Toxin

• AlphaFold DB: A0A0L8AET4