Detailed information of TA system TA125799

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-dnstrm_HI1420
• Location: 271814..272462
• Replicon: chromosome
• Accession: NZ_CP040436
• Organism: Stenotrophomonas maltophilia strain PEG-390

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: A0A0L8AET4
• Locus tag: FEO91_RS01190
• Protein ID: WP_010486984.1
• Coordinates: 271814..272101 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: A0A0U5HHQ5
• Locus tag: FEO91_RS01195
• Protein ID: WP_058979789.1
• Coordinates: 272160..272462 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEO91_RS01160	267757..268548	-	792	WP_195763048.1	zinc-dependent peptidase	-
FEO91_RS01165	268515..268793	-	279	WP_005411956.1	hypothetical protein	-
FEO91_RS01170	268938..269906	+	969	WP_019661841.1	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor	-
FEO91_RS01175	269903..270634	+	732	WP_019661840.1	type III pantothenate kinase	-
FEO91_RS01180	270644..271492	+	849	WP_155028815.1	SPOR domain-containing protein	-
FEO91_RS01190	271814..272101	+	288	WP_010486984.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FEO91_RS01195	272160..272462	+	303	WP_058979789.1	putative addiction module antidote protein	Antitoxin
FEO91_RS01200	272631..273032	-	402	WP_155028816.1	hypothetical protein	-
FEO91_RS01205	273615..274386	+	772	Protein_238	DUF3011 domain-containing protein	-
FEO91_RS01210	274411..274758	-	348	WP_057503835.1	hypothetical protein	-
FEO91_RS01215	274890..275810	+	921	WP_021203836.1	arginase	-
FEO91_RS01220	275971..276108	+	138	WP_019661832.1	entericidin A/B family lipoprotein	-
FEO91_RS01225	276310..276531	+	222	WP_019661831.1	CsbD family protein	-
FEO91_RS01230	276604..277404	-	801	WP_155028817.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	261690..274758	13068

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-90)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-95)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10744.34 Da
• Isoelectric Point: 10.8940

>T125799 WP_010486984.1 NZ_CP040436:271814-272101 [Stenotrophomonas maltophilia]
MKIQRTRQFATWIDALKDVTARARILARIGRLAEGHPGDHRYLADGVSELRIDAGPGYRVYYTQRGRQLVILLVGGDKGS
QQRDIEKAREIARAL

Nucleotide

• Length: 288 bp

>T125799 NZ_CP040436:271814-272101 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCGCGCGCTCGCATCCTGGC
CCGCATTGGACGGCTCGCCGAAGGTCACCCGGGTGACCACCGCTATCTGGCGGACGGTGTTTCCGAACTGCGTATCGATG
CAGGGCCGGGCTACCGCGTGTACTACACCCAGCGCGGCAGGCAGCTGGTGATTCTCCTGGTCGGCGGCGACAAAGGTTCG
CAGCAGCGCGATATCGAGAAGGCCAGGGAGATTGCGCGTGCCCTGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10694.26 Da
• Isoelectric Point: 8.0343

>AT125799 WP_058979789.1 NZ_CP040436:272160-272462 [Stenotrophomonas maltophilia]
MATKKKVELKAFDVAEHLRTPEEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPD
FATILKVTRALGVRLHASAA

Nucleotide

• Length: 303 bp

>AT125799 NZ_CP040436:272160-272462 [Stenotrophomonas maltophilia]
ATGGCTACCAAGAAAAAAGTCGAACTCAAAGCATTTGATGTGGCCGAACATCTTCGGACACCCGAAGAAATGGCCGCCTA
TCTCGATGCCTGCATCGAGGAAAGCGATGGCGATTCTGCCTTCATCGCCAAGGCGCTGGGCGACATCGCTCGCGCTCAGG
GCATGAGCAAGGTTGCGCGTGCGGCGGGCCTGTCGCGCGAGAGTCTTTACCGCGCACTGTCCGGCGAACGCAGCCCCGAT
TTCGCCACCATCCTGAAGGTGACACGCGCGCTGGGTGTGCGCTTGCATGCCAGTGCAGCATAA

Structures

Toxin

• AlphaFold DB: A0A0L8AET4

Antitoxin

• AlphaFold DB: A0A0U5HHQ5