Detailed information of TA system TA125797

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 3653632..3654205
• Replicon: chromosome
• Accession: NZ_CP040433
• Organism: Stenotrophomonas maltophilia strain SKK55

Toxin (Protein)

• Gene name: relE
• Uniprot ID: W5IUR0
• Locus tag: FEO94_RS16810
• Protein ID: WP_009618209.1
• Coordinates: 3653918..3654205 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: W5ISI7
• Locus tag: FEO94_RS16805
• Protein ID: WP_009618210.1
• Coordinates: 3653632..3653931 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEO94_RS16775	3648734..3648952	+	219	WP_011829925.1	AlpA family transcriptional regulator	-
FEO94_RS16780	3648993..3649859	+	867	WP_013982110.1	ParA family protein	-
FEO94_RS16785	3649843..3650079	+	237	WP_013982111.1	type II toxin-antitoxin system HicA family toxin	-
FEO94_RS16790	3650072..3651730	+	1659	WP_013982112.1	ParB family protein	-
FEO94_RS16795	3651748..3652308	+	561	WP_023912240.1	DUF2857 domain-containing protein	-
FEO94_RS16800	3652311..3653504	+	1194	WP_023912242.1	hypothetical protein	-
FEO94_RS16805	3653632..3653931	+	300	WP_009618210.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FEO94_RS16810	3653918..3654205	+	288	WP_009618209.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FEO94_RS16815	3654234..3654425	+	192	WP_011805449.1	hypothetical protein	-
FEO94_RS16820	3654549..3655328	+	780	WP_023912244.1	TIGR03761 family integrating conjugative element protein	-
FEO94_RS16825	3655325..3655873	+	549	WP_023912246.1	DUF3158 family protein	-
FEO94_RS16830	3655870..3656253	+	384	WP_004362284.1	single-stranded DNA-binding protein	-
FEO94_RS16835	3656548..3658563	+	2016	WP_154351304.1	DNA topoisomerase III	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3644412..3710348	65936

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-58)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10854.46 Da
• Isoelectric Point: 8.4628

>T125797 WP_009618209.1 NZ_CP040433:3653918-3654205 [Stenotrophomonas maltophilia]
VRVLEWREAARADLLAIVDYISDDNPDAAQRLKDDIEAKAAKLPERPKLYRPGRVAGTREMVVRANYVVVYMEDTRAVSI
LRVLHAAQQWPPARE

Nucleotide

• Length: 288 bp

>T125797 NZ_CP040433:3653918-3654205 [Stenotrophomonas maltophilia]
GTGCGCGTACTTGAGTGGCGGGAAGCTGCCCGCGCCGACCTGCTGGCGATTGTTGACTACATCTCGGACGACAACCCCGA
TGCCGCGCAGCGGTTGAAGGACGACATCGAGGCCAAGGCCGCGAAGCTGCCGGAGCGCCCGAAGCTCTACCGGCCTGGCC
GCGTGGCCGGCACGCGGGAGATGGTCGTGCGTGCGAACTACGTGGTGGTCTACATGGAGGACACCCGCGCGGTGTCCATC
CTGCGCGTGTTGCACGCCGCGCAGCAGTGGCCGCCGGCACGGGAGTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10816.46 Da
• Isoelectric Point: 8.6579

>AT125797 WP_009618210.1 NZ_CP040433:3653632-3653931 [Stenotrophomonas maltophilia]
MAAQTSMLHIRVDDKLKADAAEKLAGVGLTVSDAVRILLTRVVKEGALPAGLTADPEAYDAWFRAKVQEALADTRPPVPH
QQVMDEAQALIDRKRRART

Nucleotide

• Length: 300 bp

>AT125797 NZ_CP040433:3653632-3653931 [Stenotrophomonas maltophilia]
ATGGCCGCACAGACTTCGATGCTGCACATCCGCGTGGACGATAAGCTCAAGGCCGATGCAGCCGAGAAACTCGCCGGGGT
CGGCCTCACCGTTTCGGACGCCGTGCGCATCCTGCTGACCCGTGTGGTCAAGGAAGGCGCACTGCCGGCTGGCCTCACGG
CCGACCCGGAGGCCTACGATGCCTGGTTCCGGGCGAAGGTCCAGGAGGCGCTGGCCGACACACGGCCGCCGGTGCCGCAC
CAGCAGGTCATGGATGAGGCGCAGGCCCTGATCGACAGGAAGCGGCGTGCGCGTACTTGA

Structures

Toxin

• AlphaFold DB: A0A5R9QF16

Antitoxin

• AlphaFold DB: A0A5R9QE11