Detailed information of TA system TA125795

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-PumB/upstrm_HI1419-dnstrm_HI1420
• Location: 282420..283068
• Replicon: chromosome
• Accession: NZ_CP040432
• Organism: Stenotrophomonas maltophilia strain sm-RA9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: M5CT52
• Locus tag: FEO95_RS01180
• Protein ID: WP_004136948.1
• Coordinates: 282420..282707 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: M5D621
• Locus tag: FEO95_RS01185
• Protein ID: WP_004136950.1
• Coordinates: 282766..283068 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEO95_RS01150	278382..279170	-	789	WP_195763272.1	zinc-dependent peptidase	-
FEO95_RS01155	279137..279421	-	285	WP_012509775.1	hypothetical protein	-
FEO95_RS01160	279566..280534	+	969	WP_012509776.1	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor	-
FEO95_RS01165	280531..281262	+	732	WP_004136872.1	type III pantothenate kinase	-
FEO95_RS01170	281272..282120	+	849	WP_154354584.1	SPOR domain-containing protein	-
FEO95_RS01180	282420..282707	+	288	WP_004136948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FEO95_RS01185	282766..283068	+	303	WP_004136950.1	putative addiction module antidote protein	Antitoxin
FEO95_RS01190	283129..283614	+	486	WP_154354585.1	hypothetical protein	-
FEO95_RS01195	283871..284791	+	921	WP_004137058.1	arginase	-
FEO95_RS01200	284954..285091	+	138	WP_008266021.1	entericidin A/B family lipoprotein	-
FEO95_RS01205	285295..285516	+	222	WP_004137109.1	CsbD family protein	-
FEO95_RS01210	285590..286390	-	801	WP_004137112.1	hypothetical protein	-
FEO95_RS01215	286499..287791	+	1293	WP_004137142.1	tryptophan--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	273582..283068	9486

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (2-94)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-95)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10807.40 Da
• Isoelectric Point: 10.7813

>T125795 WP_004136948.1 NZ_CP040432:282420-282707 [Stenotrophomonas maltophilia]
MKIQRTRQFATWIDALKDVTGRARILARIGRLSEGHLGDHRYLADGVSELRIDVGPGYRVYYTQRGRQWVILLAGGDKGS
QQRDIEKAKEIARAL

Nucleotide

• Length: 288 bp

>T125795 NZ_CP040432:282420-282707 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGGGCGCGCTCGCATCCTGGC
CCGCATCGGTCGGCTCAGCGAAGGCCATCTGGGCGATCACCGCTATCTGGCCGATGGCGTTTCCGAACTGCGCATCGATG
TGGGACCGGGTTACCGCGTGTACTACACCCAGCGCGGCAGGCAGTGGGTGATTCTGCTGGCTGGCGGCGACAAGGGTTCA
CAGCAACGCGATATCGAGAAGGCCAAAGAGATTGCGCGTGCCCTGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10706.32 Da
• Isoelectric Point: 8.0343

>AT125795 WP_004136950.1 NZ_CP040432:282766-283068 [Stenotrophomonas maltophilia]
MAIKKKVELKAFDVAEHLRTPEEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPD
FATILKVTRALGVRLHASAA

Nucleotide

• Length: 303 bp

>AT125795 NZ_CP040432:282766-283068 [Stenotrophomonas maltophilia]
ATGGCCATCAAGAAGAAAGTCGAACTCAAAGCATTTGACGTGGCCGAGCACCTTCGCACACCGGAGGAGATGGCGGCCTA
TCTCGATGCCTGTATCGAAGAAAGCGATGGCGATTCTGCGTTCATTGCCAAGGCGCTCGGCGACATCGCGCGCGCTCAAG
GGATGAGCAAGGTTGCACGAGCGGCGGGCCTCTCGCGTGAGAGTCTGTATCGCGCACTGTCGGGCGAGCGCAGCCCTGAT
TTTGCGACCATCCTCAAAGTGACCCGCGCCTTGGGTGTTCGCCTGCATGCCAGCGCAGCATAA

Structures

Toxin

• AlphaFold DB: M5CT52

Antitoxin

• AlphaFold DB: M5D621