Detailed information of TA system TA125794

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 273582..274219
• Replicon: chromosome
• Accession: NZ_CP040432
• Organism: Stenotrophomonas maltophilia strain sm-RA9

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: A0A8E3U3B9
• Locus tag: FEO95_RS01125
• Protein ID: WP_065724137.1
• Coordinates: 273929..274219 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M5CST9
• Locus tag: FEO95_RS01120
• Protein ID: WP_004136660.1
• Coordinates: 273582..273890 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEO95_RS01100	269303..270193	+	891	WP_004136647.1	3-hydroxyisobutyrate dehydrogenase	-
FEO95_RS01105	270336..270761	-	426	WP_004136651.1	organic hydroperoxide resistance protein	-
FEO95_RS01110	270873..271853	-	981	WP_032968218.1	cation transporter	-
FEO95_RS01115	272071..273525	+	1455	WP_004136654.1	SulP family inorganic anion transporter	-
FEO95_RS01120	273582..273890	-	309	WP_004136660.1	putative addiction module antidote protein	Antitoxin
FEO95_RS01125	273929..274219	-	291	WP_065724137.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FEO95_RS01130	274463..275494	+	1032	WP_195763271.1	tRNA dihydrouridine(20/20a) synthase DusA	-
FEO95_RS01135	275707..276081	+	375	WP_032128191.1	hypothetical protein	-
FEO95_RS01140	276155..276838	+	684	WP_004136763.1	response regulator transcription factor	-
FEO95_RS01145	276864..278288	+	1425	WP_041864616.1	sensor histidine kinase	-
FEO95_RS01150	278382..279170	-	789	WP_195763272.1	zinc-dependent peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	273582..283068	9486

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-91)

Antitoxin

• Uncharacterized protein HI1420 (16-94)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10791.40 Da
• Isoelectric Point: 12.0078

>T125794 WP_065724137.1 NZ_CP040432:c274219-273929 [Stenotrophomonas maltophilia]
MATLQATETFTRWLRGLNDSGARAVIVERLQRVARGLEGDVRSVGRGVSELRINRGPGYRVYFTRRGRSIVVLLHGGDKS
SQRRDIEKAVRLAELL

Nucleotide

• Length: 291 bp

>T125794 NZ_CP040432:c274219-273929 [Stenotrophomonas maltophilia]
ATGGCAACCCTACAGGCAACAGAGACGTTCACGCGCTGGCTGCGCGGGCTCAACGACAGCGGCGCCCGAGCAGTGATCGT
TGAACGCCTGCAGCGCGTCGCCCGCGGTCTCGAGGGAGATGTTCGATCAGTGGGTCGTGGCGTGAGCGAACTGCGAATCA
ACCGTGGGCCGGGATATCGCGTGTATTTCACACGTCGTGGGAGATCCATCGTCGTGCTCCTGCACGGTGGCGACAAGTCG
AGCCAGCGTCGCGATATCGAAAAAGCAGTCAGGCTCGCGGAATTGCTGTAG

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 10662.10 Da
• Isoelectric Point: 6.2132

>AT125794 WP_004136660.1 NZ_CP040432:c273890-273582 [Stenotrophomonas maltophilia]
MSKLKTIPFDPADYLDDDVAIATYLSEALAAGDAGHFQEALGTVARARGMGGVAEVSGLGRESLYKALRPGAHPRFDTVQ
RVLSALGVHLIVQADKQPAGTA

Nucleotide

• Length: 309 bp

>AT125794 NZ_CP040432:c273890-273582 [Stenotrophomonas maltophilia]
ATGAGCAAGCTGAAGACGATTCCCTTCGATCCCGCCGACTATCTGGATGATGACGTCGCAATCGCCACCTATCTGAGCGA
GGCCTTGGCAGCAGGTGATGCGGGCCACTTTCAGGAGGCTCTCGGAACAGTGGCGCGTGCCCGTGGCATGGGCGGCGTTG
CCGAGGTCTCCGGTCTTGGACGCGAGAGCCTGTACAAGGCGCTGCGGCCCGGAGCACACCCACGCTTCGACACCGTGCAG
CGGGTACTGTCAGCGCTCGGGGTGCATCTCATCGTGCAAGCCGACAAGCAACCCGCTGGCACCGCCTGA

Structures

Antitoxin

• AlphaFold DB: M5CST9