Detailed information of TA system TA125793

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4969650..4970284
• Replicon: chromosome
• Accession: NZ_CP040428
• Organism: Jejubacter calystegiae strain KSNA2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FEM41_RS23320
• Protein ID: WP_006687278.1
• Coordinates: 4969650..4970054 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FEM41_RS23325
• Protein ID: WP_138098875.1
• Coordinates: 4970054..4970284 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEM41_RS23300	4964721..4966046	+	1326	WP_138098872.1	oxalate/formate MFS antiporter	-
FEM41_RS24770	4966188..4966349	+	162	WP_206665539.1	hypothetical protein	-
FEM41_RS23310	4966450..4968402	-	1953	WP_138098873.1	tetratricopeptide repeat protein	-
FEM41_RS23315	4968585..4969475	-	891	WP_138098874.1	oxidoreductase	-
FEM41_RS23320	4969650..4970054	-	405	WP_006687278.1	tRNA(fMet)-specific endonuclease VapC	Toxin
FEM41_RS23325	4970054..4970284	-	231	WP_138098875.1	antitoxin	Antitoxin
FEM41_RS23330	4970425..4970670	+	246	Protein_4556	integrase domain-containing protein	-
FEM41_RS23335	4970756..4972333	-	1578	WP_138098876.1	glutamine-hydrolyzing GMP synthase	-
FEM41_RS23340	4972399..4973865	-	1467	WP_138099312.1	IMP dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (7-53)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14977.31 Da
• Isoelectric Point: 7.8441

>T125793 WP_006687278.1 NZ_CP040428:c4970054-4969650 [Jejubacter calystegiae]
MLKYMLDTNICIYTIKNKPQAVREAFNQHYGRMCISSVTLMELIYGAEKSASPEKNLRVVEGFIARLEVLNYGIDAAVQT
GQIRAELARAGTPVGPYDSMIAAHARALGLILVTNNTREFERINGLRLEDWSIS

Nucleotide

• Length: 405 bp

>T125793 NZ_CP040428:c4970054-4969650 [Jejubacter calystegiae]
ATGCTCAAATACATGCTGGATACCAATATCTGTATCTATACGATCAAAAATAAACCTCAGGCAGTCCGGGAGGCGTTTAA
CCAGCATTACGGGCGGATGTGCATCAGTTCTGTCACGCTGATGGAGCTGATTTACGGCGCGGAGAAATCTGCCAGCCCGG
AGAAAAACCTGCGCGTGGTCGAAGGATTCATCGCCCGGTTGGAGGTGCTGAATTATGGTATCGATGCGGCGGTACAGACG
GGGCAAATCCGGGCAGAACTGGCAAGAGCAGGTACGCCCGTTGGCCCGTATGACAGCATGATTGCGGCCCACGCCCGCGC
ACTGGGTTTAATTCTGGTGACGAACAATACCCGTGAGTTCGAACGTATTAATGGATTACGTCTGGAAGACTGGAGTATCA
GCTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8537.50 Da
• Isoelectric Point: 4.5859

>AT125793 WP_138098875.1 NZ_CP040428:c4970284-4970054 [Jejubacter calystegiae]
MEKTTVFKSNRSQAVRLPKAVALPEDVKHVDIVAVGRTRIITPAGESWDSWFDGESVTSDFMAAREQPGDQDREEF

Nucleotide

• Length: 231 bp

>AT125793 NZ_CP040428:c4970284-4970054 [Jejubacter calystegiae]
ATGGAAAAGACAACCGTATTCAAAAGCAACCGTAGCCAGGCGGTGCGTCTGCCAAAAGCGGTGGCTTTACCGGAGGATGT
CAAACACGTGGATATCGTCGCGGTAGGGCGAACGCGCATTATTACTCCCGCAGGCGAAAGTTGGGACAGCTGGTTTGATG
GTGAGAGCGTGACGTCTGACTTTATGGCCGCCCGTGAACAGCCAGGTGACCAGGACCGGGAAGAGTTCTGA