Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 4498155..4498745 Replicon chromosome
Accession NZ_CP040428
Organism Jejubacter calystegiae strain KSNA2

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag FEM41_RS21120 Protein ID WP_138098142.1
Coordinates 4498155..4498487 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag FEM41_RS21125 Protein ID WP_138098144.1
Coordinates 4498488..4498745 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEM41_RS21080 4493507..4493770 - 264 WP_138098130.1 hypothetical protein -
FEM41_RS21085 4493914..4494087 - 174 WP_138098132.1 GhoT/OrtT family toxin -
FEM41_RS21090 4494388..4494576 - 189 WP_138098134.1 hypothetical protein -
FEM41_RS21095 4495103..4495942 - 840 WP_138098136.1 DUF817 domain-containing protein -
FEM41_RS21100 4496005..4496454 - 450 WP_138098138.1 hypothetical protein -
FEM41_RS21110 4497139..4497924 + 786 WP_138098140.1 DgsA anti-repressor MtfA -
FEM41_RS21120 4498155..4498487 - 333 WP_138098142.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FEM41_RS21125 4498488..4498745 - 258 WP_138098144.1 antitoxin Antitoxin
FEM41_RS21130 4498842..4499033 + 192 WP_138098146.1 hypothetical protein -
FEM41_RS21135 4499092..4499298 - 207 WP_138098148.1 helix-turn-helix domain-containing protein -
FEM41_RS21140 4499373..4500803 - 1431 WP_138098150.1 heavy metal sensor histidine kinase -
FEM41_RS21145 4500800..4501471 - 672 WP_138098152.1 heavy metal response regulator transcription factor -
FEM41_RS21150 4501610..4502236 + 627 WP_138098154.1 hypothetical protein -
FEM41_RS21155 4502251..4502859 + 609 WP_138098156.1 cytochrome b/b6 domain-containing protein -
FEM41_RS21160 4502849..4503616 + 768 WP_138098158.1 molybdopterin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11767.64 Da        Isoelectric Point: 10.5834

>T125792 WP_138098142.1 NZ_CP040428:c4498487-4498155 [Jejubacter calystegiae]
MDRGEIWLVSLDPIAGHEQSGKRLVLIVSKASFNKLTRLPVVVPVTSGGNFARAAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARSGKRLERIPDAVVNEVLARLEAILN

Download         Length: 333 bp

>T125792 NZ_CP040428:c4498487-4498155 [Jejubacter calystegiae]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCCGGTCACGAGCAAAGCGGAAAACGTCTGGTGCTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACGCGGCTACCCGTTGTTGTTCCCGTCACCAGCGGTGGAAACTTTGCCCGCG
CAGCCGGTTTTACCGTCTCACTGGATGGTGCGGGAACAAAAACAACGGGCGTTATTCGCTGCGACCAGCCCAGAACGATT
GATATGGGAGCCCGGAGTGGTAAGCGGCTGGAACGTATACCTGATGCTGTCGTGAATGAAGTGCTGGCCAGGCTGGAGGC
TATTCTGAATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9370.85 Da        Isoelectric Point: 4.4488

>AT125792 WP_138098144.1 NZ_CP040428:c4498745-4498488 [Jejubacter calystegiae]
MYTTRLKKVGGSIMLAVPPAVLKTLGLSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp

>AT125792 NZ_CP040428:c4498745-4498488 [Jejubacter calystegiae]
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGGGCT
GTCGACGGACAGCGAAGTGGGCATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAGCGGCCCCGTTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCATGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References