Detailed information of TA system TA125783

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4139704..4140305
• Replicon: chromosome
• Accession: NZ_CP040428
• Organism: Jejubacter calystegiae strain KSNA2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FEM41_RS19180
• Protein ID: WP_138097776.1
• Coordinates: 4139704..4139889 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FEM41_RS19185
• Protein ID: WP_138097777.1
• Coordinates: 4139892..4140305 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEM41_RS19150	4135448..4136461	-	1014	WP_138097772.1	two-component system response regulator RssB	-
FEM41_RS19155	4136558..4137445	-	888	WP_138097773.1	patatin-like phospholipase RssA	-
FEM41_RS19160	4137557..4138015	+	459	WP_138097774.1	YchJ family protein	-
FEM41_RS19165	4138062..4138904	+	843	WP_138097775.1	formyltetrahydrofolate deformylase	-
FEM41_RS19180	4139704..4139889	+	186	WP_138097776.1	type II toxin-antitoxin system HicA family toxin	Toxin
FEM41_RS19185	4139892..4140305	+	414	WP_138097777.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FEM41_RS19190	4140350..4141027	-	678	WP_138097778.1	respiratory nitrate reductase subunit gamma	-
FEM41_RS19195	4141027..4141737	-	711	WP_138097779.1	nitrate reductase molybdenum cofactor assembly chaperone	-
FEM41_RS19200	4141730..4143265	-	1536	WP_138097780.1	nitrate reductase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7049.31 Da
• Isoelectric Point: 10.8832

>T125783 WP_138097776.1 NZ_CP040428:4139704-4139889 [Jejubacter calystegiae]
VKSAELIKRLEKNGWILERIKGSHHQFSHPDFSIVITVPHPRKDMKPGTLHQILKSAKLKE

Nucleotide

• Length: 186 bp

>T125783 NZ_CP040428:4139704-4139889 [Jejubacter calystegiae]
GTGAAAAGCGCGGAACTTATCAAACGACTGGAGAAAAACGGTTGGATTCTTGAACGAATAAAAGGTAGCCATCATCAGTT
CTCCCATCCGGACTTTTCGATCGTTATCACGGTTCCGCATCCACGCAAAGATATGAAACCGGGAACGCTTCATCAAATTC
TGAAGAGCGCGAAACTTAAGGAGTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15431.25 Da
• Isoelectric Point: 4.6243

>AT125783 WP_138097777.1 NZ_CP040428:4139892-4140305 [Jejubacter calystegiae]
MLYPAFIEVDTDGTASGWFPDVPGCTFAGDTIEDAFIDARSAIEAHFELLSEKEREIPTPHRIEEHANAKGSDGLNGRWL
YIDINMDKFDGRAERINITLPHRLLERIDATVKQQPEYGSRSAFLAAAAREELLKNR

Nucleotide

• Length: 414 bp

>AT125783 NZ_CP040428:4139892-4140305 [Jejubacter calystegiae]
ATGCTCTACCCTGCTTTCATTGAAGTCGATACTGACGGTACAGCCAGCGGCTGGTTTCCGGACGTTCCGGGGTGTACCTT
CGCCGGTGATACCATCGAAGACGCTTTTATCGATGCACGCAGCGCTATAGAAGCACACTTTGAGCTGCTGAGTGAAAAAG
AGCGAGAAATACCAACGCCGCATCGCATTGAAGAGCATGCTAACGCGAAGGGCAGCGACGGCCTGAATGGTCGCTGGCTC
TACATTGATATCAATATGGATAAATTTGACGGACGCGCTGAGCGTATCAATATTACGCTTCCGCACCGGCTACTTGAGCG
CATAGACGCCACCGTTAAACAGCAGCCTGAGTACGGTAGCCGCAGCGCTTTTCTGGCCGCGGCCGCACGCGAAGAACTTC
TTAAAAACCGTTAA