Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4011934..4012526 Replicon chromosome
Accession NZ_CP040428
Organism Jejubacter calystegiae strain KSNA2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FEM41_RS18535 Protein ID WP_138097662.1
Coordinates 4011934..4012188 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FEM41_RS18540 Protein ID WP_138097663.1
Coordinates 4012185..4012526 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEM41_RS18520 4008671..4009951 + 1281 WP_138097659.1 type 1 fimbrial protein -
FEM41_RS18525 4009997..4010599 - 603 WP_138097660.1 phenylacetic acid degradation protein PaaY -
FEM41_RS18530 4010609..4011535 - 927 WP_138097661.1 phenylacetic acid degradation operon negative regulatory protein PaaX -
FEM41_RS18535 4011934..4012188 + 255 WP_138097662.1 type II toxin-antitoxin system HicA family toxin Toxin
FEM41_RS18540 4012185..4012526 + 342 WP_138097663.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FEM41_RS18545 4012577..4013878 - 1302 WP_138097664.1 phenylacetate--CoA ligase -
FEM41_RS18550 4014032..4014442 - 411 WP_138097665.1 hydroxyphenylacetyl-CoA thioesterase PaaI -
FEM41_RS18555 4014432..4015943 - 1512 WP_138097666.1 3-hydroxyacyl-CoA dehydrogenase -
FEM41_RS18560 4015945..4016733 - 789 WP_138097667.1 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase PaaG -
FEM41_RS18565 4016736..4017503 - 768 WP_138097668.1 2,3-dehydroadipyl-CoA hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-77)

Antitoxin

Uncharacterised protein family HicB

(55-99)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9629.21 Da        Isoelectric Point: 11.2749

>T125782 WP_138097662.1 NZ_CP040428:4011934-4012188 [Jejubacter calystegiae]
MNKRHQKTLSDLFKHPVSGSIKWSEIESLFIALGAEIHEREGSRIAVLLRGEKRIFHRPHPRPTTDKGAVNAIRIWLDVL
GIRP

Download         Length: 255 bp

>T125782 NZ_CP040428:4011934-4012188 [Jejubacter calystegiae]
ATGAACAAACGACATCAAAAGACGCTGTCCGATCTGTTCAAACACCCGGTGAGTGGATCGATAAAATGGTCAGAGATTGA
ATCTCTGTTTATTGCTCTCGGGGCAGAGATCCATGAACGTGAAGGTTCAAGAATTGCTGTTTTATTACGGGGTGAAAAAC
GGATATTTCACCGCCCGCACCCAAGGCCAACCACCGACAAGGGAGCAGTAAACGCTATCAGGATATGGTTAGATGTATTA
GGAATAAGACCATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12600.40 Da        Isoelectric Point: 5.2068

>AT125782 WP_138097663.1 NZ_CP040428:4012185-4012526 [Jejubacter calystegiae]
MINILKIDGHQAIITFDPEIEMFRGEFTGLNGGADFYARSVDELKKEGEESLRIFLDECRKDGIAPYKSFSGKVTTRLTP
ERHQALTIAAQATGMSINEMLNEGVDLVLKKHA

Download         Length: 342 bp

>AT125782 NZ_CP040428:4012185-4012526 [Jejubacter calystegiae]
ATGATCAATATACTTAAAATCGACGGCCATCAGGCAATCATCACCTTTGACCCTGAAATTGAGATGTTCCGCGGTGAATT
TACCGGGCTCAATGGCGGCGCCGATTTCTACGCCAGGAGCGTAGATGAGCTAAAAAAAGAAGGCGAAGAATCACTGCGTA
TATTCCTTGATGAATGCCGTAAAGATGGAATAGCCCCCTATAAATCTTTTAGCGGTAAGGTGACAACCCGCCTGACCCCG
GAGCGCCATCAGGCACTGACTATCGCCGCACAGGCTACGGGGATGTCCATTAATGAAATGTTGAATGAAGGCGTTGACCT
GGTACTTAAAAAACACGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References