Detailed information of TA system TA125781

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 3079550..3080193
• Replicon: chromosome
• Accession: NZ_CP040428
• Organism: Jejubacter calystegiae strain KSNA2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FEM41_RS14155
• Protein ID: WP_138096577.1
• Coordinates: 3080011..3080193 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FEM41_RS14150
• Protein ID: WP_138096576.1
• Coordinates: 3079550..3079978 (-)
• Length: 143 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEM41_RS14120	3074564..3075286	+	723	WP_138096571.1	oxygen-insensitive NADPH nitroreductase	-
FEM41_RS14125	3075334..3076236	+	903	WP_138096572.1	30S ribosomal protein S6--L-glutamate ligase	-
FEM41_RS14130	3076327..3076806	+	480	WP_138096573.1	YbjN domain-containing protein	-
FEM41_RS14135	3076954..3077454	+	501	WP_196240487.1	YbjO family protein	-
FEM41_RS14140	3077498..3078628	+	1131	WP_138096574.1	23S rRNA (uracil(747)-C(5))-methyltransferase RlmC	-
FEM41_RS14145	3078674..3079408	-	735	WP_138096575.1	ABC transporter substrate-binding protein ArtJ	-
FEM41_RS14150	3079550..3079978	-	429	WP_138096576.1	hypothetical protein	Antitoxin
FEM41_RS14155	3080011..3080193	-	183	WP_138096577.1	type II toxin-antitoxin system HicA family toxin	Toxin
FEM41_RS14160	3080359..3081027	-	669	WP_138096578.1	arginine ABC transporter permease ArtM	-
FEM41_RS14165	3081027..3081743	-	717	WP_138096579.1	arginine ABC transporter permease ArtQ	-
FEM41_RS14170	3081752..3082483	-	732	WP_138096580.1	arginine ABC transporter substrate-binding protein	-
FEM41_RS14175	3082504..3083232	-	729	WP_138096581.1	arginine ABC transporter ATP-binding protein ArtP	-
FEM41_RS14180	3083450..3083965	-	516	WP_138096582.1	lipoprotein	-
FEM41_RS14185	3084102..3084425	+	324	WP_138096583.1	heavy metal-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-82)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6839.96 Da
• Isoelectric Point: 10.8173

>T125781 WP_138096577.1 NZ_CP040428:c3080193-3080011 [Jejubacter calystegiae]
MKYSEFKRWLLQQGAEFAKAPGGGSHQKINLNGRRSVFPDHGSKEMPEPLRKKIMKDLGL

Nucleotide

• Length: 183 bp

>T125781 NZ_CP040428:c3080193-3080011 [Jejubacter calystegiae]
ATGAAATACAGCGAATTTAAACGTTGGCTACTGCAACAGGGTGCAGAGTTCGCTAAAGCGCCAGGGGGAGGAAGCCACCA
GAAGATCAATTTGAACGGCAGAAGATCGGTTTTCCCCGACCATGGTTCCAAAGAGATGCCGGAACCACTACGCAAGAAAA
TCATGAAGGATTTAGGACTTTGA

Antitoxin

Protein

• Length: 143 a.a.
• Molecular weight: 15368.56 Da
• Isoelectric Point: 5.1991

>AT125781 WP_138096576.1 NZ_CP040428:c3079978-3079550 [Jejubacter calystegiae]
MYNYPVKLTHDAETNSWIASCRDLPLMNSVGDSIEEALLESVYGLVTAVAIEIEERRPVPQGSAPQAGEYIVSLPVLAAM
KAALHNAMIETGTRKADLARKLGKTGTQIDRLLDVEHSSKVETVELALHQLNRSIAVSVTAS

Nucleotide

• Length: 429 bp

>AT125781 NZ_CP040428:c3079978-3079550 [Jejubacter calystegiae]
ATGTATAACTACCCGGTAAAACTCACTCATGACGCAGAGACAAATAGTTGGATAGCCTCATGTCGGGATCTGCCTTTAAT
GAACTCCGTGGGTGACTCTATTGAAGAAGCCTTACTGGAGTCCGTTTATGGCCTGGTGACGGCAGTCGCCATTGAAATCG
AGGAGCGCAGGCCCGTCCCCCAGGGTAGTGCCCCCCAGGCAGGTGAATATATTGTCTCACTGCCCGTGCTGGCGGCAATG
AAAGCCGCACTGCACAACGCGATGATCGAGACCGGTACCCGAAAAGCCGATCTGGCCCGCAAGCTGGGAAAAACGGGAAC
TCAAATAGACAGGCTCCTGGATGTGGAACACTCATCAAAAGTAGAGACCGTAGAGCTGGCACTACACCAGTTAAACAGAA
GCATCGCAGTCTCAGTCACCGCCAGTTAG