Detailed information of TA system TA125779

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 2652391..2652941
• Replicon: chromosome
• Accession: NZ_CP040428
• Organism: Jejubacter calystegiae strain KSNA2

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: FEM41_RS12120
• Protein ID: WP_138096218.1
• Coordinates: 2652391..2652699 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: FEM41_RS12125
• Protein ID: WP_138096219.1
• Coordinates: 2652702..2652941 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEM41_RS12105	2648468..2649832	+	1365	WP_138096215.1	HlyD family type I secretion periplasmic adaptor subunit	-
FEM41_RS12110	2649982..2651673	+	1692	WP_138096216.1	sensor histidine kinase	-
FEM41_RS12115	2651667..2652386	+	720	WP_138096217.1	two-component system response regulator BtsR	-
FEM41_RS12120	2652391..2652699	-	309	WP_138096218.1	CcdB family protein	Toxin
FEM41_RS12125	2652702..2652941	-	240	WP_138096219.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
FEM41_RS12130	2653066..2655219	-	2154	WP_138096220.1	carbon starvation protein A	-
FEM41_RS12135	2655487..2656809	-	1323	WP_138096221.1	NCS2 family nucleobase:cation symporter	-
FEM41_RS12140	2656820..2657335	-	516	WP_138096222.1	flavin reductase	-
FEM41_RS12145	2657346..2657936	-	591	WP_138096223.1	malonic semialdehyde reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (9-79)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11821.69 Da
• Isoelectric Point: 6.7225

>T125779 WP_138096218.1 NZ_CP040428:c2652699-2652391 [Jejubacter calystegiae]
MQYRIYRNNGNSKAYPYLLDVQSNIIDELHTLLVIPLFPATQMRTQPVKRLTPLIAIEGHDYLVMTHEMASVRRTQLGNE
VMDASPWRQEIKAALDFMLDGF

Nucleotide

• Length: 309 bp

>T125779 NZ_CP040428:c2652699-2652391 [Jejubacter calystegiae]
ATGCAATATCGAATTTATCGTAATAACGGCAACAGCAAGGCGTACCCTTATCTGCTTGATGTTCAAAGCAATATTATCGA
TGAGTTGCACACTCTCCTGGTTATTCCCCTATTCCCGGCTACGCAGATGCGTACACAACCGGTAAAACGCCTGACACCAT
TGATTGCCATTGAAGGTCACGACTATCTGGTCATGACCCATGAAATGGCCAGCGTCCGGCGTACTCAACTGGGTAACGAG
GTCATGGATGCCAGCCCCTGGCGCCAGGAAATCAAGGCCGCGCTGGATTTTATGCTGGATGGATTCTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9003.08 Da
• Isoelectric Point: 5.7012

>AT125779 WP_138096219.1 NZ_CP040428:c2652941-2652702 [Jejubacter calystegiae]
MSQAYAQPKKTISVTLEPWLLQQARAAGINLSATLAEALKHEIRKNEEEAWKRENRAGLQELNRISDEHGLLSDDDRTF

Nucleotide

• Length: 240 bp

>AT125779 NZ_CP040428:c2652941-2652702 [Jejubacter calystegiae]
ATGTCACAAGCTTATGCCCAACCTAAAAAGACCATCAGCGTAACGCTGGAACCCTGGCTACTGCAGCAGGCCAGAGCTGC
CGGGATCAATTTGTCCGCAACCCTGGCGGAAGCGCTAAAGCACGAAATTCGCAAAAATGAAGAAGAGGCATGGAAACGGG
AAAACCGCGCCGGACTCCAGGAGCTCAACCGAATTTCCGATGAGCATGGACTGCTGTCTGACGATGACCGGACATTTTAA