Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2423017..2423638 Replicon chromosome
Accession NZ_CP040428
Organism Jejubacter calystegiae strain KSNA2

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag FEM41_RS11175 Protein ID WP_138096046.1
Coordinates 2423017..2423235 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag FEM41_RS11180 Protein ID WP_138096047.1
Coordinates 2423264..2423638 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEM41_RS11145 2418054..2418461 - 408 WP_138096041.1 hypothetical protein -
FEM41_RS11150 2418635..2419207 - 573 WP_138096042.1 TetR family transcriptional regulator -
FEM41_RS11155 2419334..2420827 + 1494 WP_138096043.1 SmvA family efflux MFS transporter -
FEM41_RS11160 2420828..2421373 - 546 WP_138099167.1 flavin reductase family protein -
FEM41_RS11165 2421430..2422146 - 717 WP_138096044.1 GNAT family N-acetyltransferase -
FEM41_RS11170 2422179..2422670 - 492 WP_138096045.1 YlaC family protein -
FEM41_RS11175 2423017..2423235 - 219 WP_138096046.1 hemolysin expression modulator Hha Toxin
FEM41_RS11180 2423264..2423638 - 375 WP_138096047.1 Hha toxicity modulator TomB Antitoxin
FEM41_RS11185 2424100..2427249 - 3150 WP_138096048.1 multidrug efflux RND transporter permease subunit AcrB -
FEM41_RS11190 2427272..2428471 - 1200 WP_138096049.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8637.05 Da        Isoelectric Point: 9.4832

>T125778 WP_138096046.1 NZ_CP040428:c2423235-2423017 [Jejubacter calystegiae]
MTTKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDHELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T125778 NZ_CP040428:c2423235-2423017 [Jejubacter calystegiae]
ATGACAACCAAGCCGTTAACCAAGACAGACTATCTGATGCGTCTGCGCCGCTGCCAGACTATCGATACGCTGGAGCGTGT
TATCGAAAAAAATAAATACGAATTATCAGACCATGAACTGGCGGTATTTTATTCAGCTGCTGACCACCGCCTGGCTGAAC
TCACGATGAACAAGCTTTACGATAAAATCCCGACGTCTGTGTGGAAATTTGTCCGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14610.29 Da        Isoelectric Point: 4.4378

>AT125778 WP_138096047.1 NZ_CP040428:c2423638-2423264 [Jejubacter calystegiae]
MDEYSPKRHDIAQLKYLCENLYHDCLARLDDGTPGWVNDPTATVNLQLNDLIEHIATFALNYKIKYEDESRLTQQIDEYL
DDTFMLFSNYGINAQDLQQWYKSSRRLFQCFVNESRANPVSLSF

Download         Length: 375 bp

>AT125778 NZ_CP040428:c2423638-2423264 [Jejubacter calystegiae]
ATGGACGAATACTCACCGAAGCGGCATGATATAGCGCAGCTAAAATATCTCTGCGAGAACCTGTATCACGACTGCCTGGC
AAGGCTCGACGATGGCACCCCCGGCTGGGTTAATGACCCGACCGCCACCGTCAATCTGCAGTTGAATGATTTGATTGAGC
ATATAGCGACCTTCGCACTTAATTACAAGATTAAGTACGAAGATGAGAGTAGGTTAACCCAACAAATAGACGAATATCTG
GACGACACCTTCATGTTGTTTAGCAACTACGGCATTAATGCACAGGATTTGCAACAATGGTACAAATCCAGCCGTCGCTT
GTTCCAGTGTTTCGTCAATGAAAGCAGAGCCAACCCGGTAAGCCTTTCATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References