Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 2366655..2367268 Replicon chromosome
Accession NZ_CP040428
Organism Jejubacter calystegiae strain KSNA2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FEM41_RS10920 Protein ID WP_138095998.1
Coordinates 2366655..2366831 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FEM41_RS10925 Protein ID WP_138095999.1
Coordinates 2366846..2367268 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEM41_RS10900 2361702..2363567 - 1866 WP_138095994.1 1-deoxy-D-xylulose-5-phosphate synthase -
FEM41_RS10905 2363590..2364489 - 900 WP_138095995.1 (2E,6E)-farnesyl diphosphate synthase -
FEM41_RS10910 2364489..2364731 - 243 WP_138095996.1 exodeoxyribonuclease VII small subunit -
FEM41_RS10915 2364949..2366397 + 1449 WP_138095997.1 tRNA 4-thiouridine(8) synthase ThiI -
FEM41_RS10920 2366655..2366831 + 177 WP_138095998.1 type II toxin-antitoxin system HicA family toxin Toxin
FEM41_RS10925 2366846..2367268 + 423 WP_138095999.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FEM41_RS10930 2367269..2367862 - 594 WP_138096000.1 protein deglycase YajL -
FEM41_RS10935 2367825..2368736 - 912 WP_138096001.1 2-dehydropantoate 2-reductase -
FEM41_RS10940 2368871..2369362 + 492 WP_138096002.1 YajQ family cyclic di-GMP-binding protein -
FEM41_RS10945 2369401..2370771 - 1371 WP_138096003.1 MFS transporter -
FEM41_RS10950 2370918..2371805 - 888 WP_138096004.1 heme o synthase -
FEM41_RS10955 2371816..2372145 - 330 WP_138096005.1 cytochrome o ubiquinol oxidase subunit IV -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(81-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6949.15 Da        Isoelectric Point: 12.0950

>T125777 WP_138095998.1 NZ_CP040428:2366655-2366831 [Jejubacter calystegiae]
MKQREFRRFLARQGATFVEGRSHVKIYLNGRQCVMPRHPGRELNESLRRAILRQLDII

Download         Length: 177 bp

>T125777 NZ_CP040428:2366655-2366831 [Jejubacter calystegiae]
ATGAAGCAGAGGGAATTCCGGCGTTTCCTGGCCCGCCAGGGAGCCACCTTCGTTGAAGGGAGAAGCCATGTGAAGATCTA
TCTTAATGGCCGGCAGTGTGTGATGCCTCGCCATCCGGGCAGGGAGCTGAATGAGAGTCTGCGCAGGGCGATTTTGCGGC
AGCTCGATATCATTTAA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15414.50 Da        Isoelectric Point: 4.4202

>AT125777 WP_138095999.1 NZ_CP040428:2366846-2367268 [Jejubacter calystegiae]
MRYKVNLEVAQEGGWFVSFPDIPEALTQGDSREEALAMAQDALVTAFDFYFEDGRQIPAPASIQRDDNWVDVPASVAAKV
ILLNALLEAEISQADLARRLRTRPQEVSRIVNLAHPTKIDTIERALAALGLRLELSATPG

Download         Length: 423 bp

>AT125777 NZ_CP040428:2366846-2367268 [Jejubacter calystegiae]
ATGCGTTATAAGGTTAATCTTGAAGTGGCACAGGAGGGGGGATGGTTTGTCTCTTTCCCCGATATTCCTGAGGCTCTTAC
CCAGGGCGACAGTCGTGAGGAAGCACTGGCGATGGCTCAGGACGCCCTGGTGACTGCGTTTGATTTCTACTTCGAAGATG
GTCGCCAGATTCCGGCTCCGGCGAGCATTCAACGCGATGATAACTGGGTCGATGTGCCCGCCAGCGTTGCAGCGAAGGTG
ATATTGCTTAATGCGCTGCTGGAAGCGGAGATCTCTCAGGCCGATTTGGCGCGCCGTTTACGTACCCGTCCCCAGGAGGT
GTCCCGTATTGTAAACCTGGCGCATCCGACCAAAATCGATACTATTGAGCGGGCGCTGGCGGCATTGGGGCTGCGCCTGG
AACTGTCCGCGACTCCGGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References