125772

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 2762..3350 Replicon plasmid pPB364_2
Accession NZ_CP040427
Organism Acinetobacter baumannii strain PB364

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag FE003_RS20245 Protein ID WP_000438826.1
Coordinates 2762..3049 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag FE003_RS20250 Protein ID WP_001983304.1
Coordinates 3036..3350 (+) Length 105 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE003_RS20230 1..951 + 951 WP_001208778.1 replication initiation protein RepM -
FE003_RS20235 944..1519 + 576 WP_001096619.1 helix-turn-helix domain-containing protein -
FE003_RS20435 1539..1682 + 144 WP_001125246.1 hypothetical protein -
FE003_RS20240 1871..2389 - 519 WP_000447193.1 sel1 repeat family protein -
FE003_RS20245 2762..3049 + 288 WP_000438826.1 BrnT family toxin Toxin
FE003_RS20250 3036..3350 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
FE003_RS20255 3478..5889 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
FE003_RS20260 6194..6655 + 462 WP_000761346.1 DIP1984 family protein -
FE003_RS20265 7091..8116 - 1026 WP_001988464.1 IS30-like element ISAba125 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10967 10967
- flank IS/Tn - - 7091..8116 1025


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T125772 WP_000438826.1 NZ_CP040427:2762-3049 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T125772 NZ_CP040427:2762-3049 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT125772 WP_001983304.1 NZ_CP040427:3036-3350 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT125772 NZ_CP040427:3036-3350 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6


Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References