125768

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 720132..720622 Replicon chromosome
Accession NZ_CP040423
Organism Dolosigranulum pigrum strain KPL3043

Toxin (Protein)


Gene name relE Uniprot ID H3NFC0
Locus tag FE322_RS03395 Protein ID WP_004636454.1
Coordinates 720356..720622 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H3NFC1
Locus tag FE322_RS03390 Protein ID WP_004636455.1
Coordinates 720132..720359 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE322_RS03380 (FE322_03400) 715315..717168 + 1854 WP_208953663.1 oligopeptide ABC transporter substrate-binding protein -
FE322_RS03385 (FE322_03405) 717245..719797 - 2553 WP_208969607.1 transglycosylase domain-containing protein -
FE322_RS03390 (FE322_03410) 720132..720359 + 228 WP_004636455.1 DUF6290 family protein Antitoxin
FE322_RS03395 (FE322_03415) 720356..720622 + 267 WP_004636454.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FE322_RS03400 (FE322_03420) 720734..721699 - 966 WP_208953665.1 rhodanese-related sulfurtransferase -
FE322_RS03405 (FE322_03425) 721835..723640 - 1806 WP_208969608.1 M3 family oligoendopeptidase -
FE322_RS03410 (FE322_03430) 723794..724261 - 468 WP_208953667.1 universal stress protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10367.24 Da        Isoelectric Point: 10.5009

>T125768 WP_004636454.1 NZ_CP040423:720356-720622 [Dolosigranulum pigrum]
MSYQLMLSNKARKQLKKLDPPVAEMIIRWLKANVDGVDNPRKHGKALTGEYKDLWRYRVGNYRIICDVRDRELIILALAV
GHRKDIYK

Download         Length: 267 bp

>T125768 NZ_CP040423:720356-720622 [Dolosigranulum pigrum]
ATGAGCTACCAGTTAATGTTAAGCAACAAAGCTAGAAAGCAACTTAAAAAGTTAGACCCTCCCGTAGCTGAGATGATTAT
ACGATGGTTGAAAGCTAATGTGGATGGTGTAGATAATCCTAGAAAGCATGGTAAGGCACTGACAGGGGAATATAAAGACT
TATGGCGTTATCGTGTAGGGAATTATCGTATTATTTGTGATGTGAGAGATAGAGAACTAATTATATTAGCATTAGCAGTT
GGACATCGAAAAGATATTTACAAGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8473.61 Da        Isoelectric Point: 3.9947

>AT125768 WP_004636455.1 NZ_CP040423:720132-720359 [Dolosigranulum pigrum]
MAIVSVRLNKEEEQVINGYALLTGQPISQLFKQALIREIEDQLDYKVGIKALAEHEDDPQTFTLEDMADELGINL

Download         Length: 228 bp

>AT125768 NZ_CP040423:720132-720359 [Dolosigranulum pigrum]
ATGGCAATTGTATCTGTACGACTGAATAAAGAAGAAGAGCAAGTAATTAATGGATATGCCTTATTGACAGGTCAACCGAT
ATCACAATTATTTAAGCAAGCGTTGATTAGAGAGATTGAAGATCAACTAGACTACAAGGTGGGGATTAAAGCGTTAGCTG
AGCACGAGGATGACCCTCAGACATTTACCTTAGAGGATATGGCAGATGAGTTAGGAATTAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S8KMK3

Antitoxin

Source ID Structure
AlphaFold DB A0A1S8KLU2

References