Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 822538..823028 Replicon chromosome
Accession NZ_CP040422
Organism Dolosigranulum pigrum strain KPL3050

Toxin (Protein)


Gene name relE Uniprot ID H3NFC0
Locus tag FE323_RS03900 Protein ID WP_004636454.1
Coordinates 822762..823028 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H3NFC1
Locus tag FE323_RS03895 Protein ID WP_004636455.1
Coordinates 822538..822765 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE323_RS03885 (FE323_03830) 817721..819574 + 1854 WP_208959724.1 oligopeptide ABC transporter substrate-binding protein -
FE323_RS03890 (FE323_03835) 819651..822203 - 2553 WP_208959725.1 transglycosylase domain-containing protein -
FE323_RS03895 (FE323_03840) 822538..822765 + 228 WP_004636455.1 DUF6290 family protein Antitoxin
FE323_RS03900 (FE323_03845) 822762..823028 + 267 WP_004636454.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FE323_RS03905 (FE323_03850) 823138..824103 - 966 WP_111950672.1 rhodanese-related sulfurtransferase -
FE323_RS03910 (FE323_03855) 824239..826044 - 1806 WP_208959726.1 M3 family oligoendopeptidase -
FE323_RS03915 (FE323_03860) 826199..826666 - 468 WP_208956278.1 universal stress protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10367.24 Da        Isoelectric Point: 10.5009

>T125767 WP_004636454.1 NZ_CP040422:822762-823028 [Dolosigranulum pigrum]
MSYQLMLSNKARKQLKKLDPPVAEMIIRWLKANVDGVDNPRKHGKALTGEYKDLWRYRVGNYRIICDVRDRELIILALAV
GHRKDIYK

Download         Length: 267 bp

>T125767 NZ_CP040422:822762-823028 [Dolosigranulum pigrum]
ATGAGCTACCAGTTAATGTTAAGCAACAAAGCTAGAAAACAACTTAAAAAGTTAGACCCTCCCGTAGCTGAGATGATTAT
ACGGTGGTTGAAAGCTAATGTGGATGGTGTAGATAACCCTAGAAAGCATGGTAAGGCACTGACAGGGGAATATAAAGACT
TATGGCGTTATCGTGTAGGGAATTATCGTATTATTTGTGATGTGAGAGATAGAGAACTAATTATATTAGCATTAGCAGTT
GGACATCGAAAAGATATTTACAAGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8473.61 Da        Isoelectric Point: 3.9947

>AT125767 WP_004636455.1 NZ_CP040422:822538-822765 [Dolosigranulum pigrum]
MAIVSVRLNKEEEQVINGYALLTGQPISQLFKQALIREIEDQLDYKVGIKALAEHEDDPQTFTLEDMADELGINL

Download         Length: 228 bp

>AT125767 NZ_CP040422:822538-822765 [Dolosigranulum pigrum]
ATGGCAATTGTATCTGTACGACTGAATAAAGAAGAAGAGCAAGTAATTAATGGATATGCCTTATTGACAGGTCAACCGAT
ATCACAATTATTTAAGCAAGCGTTGATTAGAGAGATTGAAGATCAACTAGACTACAAGGTGGGGATTAAAGCGTTAGCTG
AGCACGAGGATGACCCTCAGACATTTACCTTAGAGGATATGGCAGATGAGTTAGGAATTAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S8KMK3

Antitoxin

Source ID Structure
AlphaFold DB A0A1S8KLU2

References