Detailed information of TA system TA125766

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 786405..786895
• Replicon: chromosome
• Accession: NZ_CP040421
• Organism: Dolosigranulum pigrum strain KPL3052

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FE324_RS03850
• Protein ID: WP_208958898.1
• Coordinates: 786629..786895 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FE324_RS03845
• Protein ID: WP_208958897.1
• Coordinates: 786405..786632 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FE324_RS03835 (FE324_03820)	781832..782836	+	1005	WP_004636458.1	catabolite control protein A	-
FE324_RS03840 (FE324_03825)	783552..786104	-	2553	WP_208958896.1	transglycosylase domain-containing protein	-
FE324_RS03845 (FE324_03830)	786405..786632	+	228	WP_208958897.1	DUF6290 family protein	Antitoxin
FE324_RS03850 (FE324_03835)	786629..786895	+	267	WP_208958898.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FE324_RS03855 (FE324_03840)	787006..787971	-	966	WP_111950672.1	rhodanese-related sulfurtransferase	-
FE324_RS03860 (FE324_03845)	788107..789912	-	1806	WP_208958899.1	M3 family oligoendopeptidase	-
FE324_RS03865 (FE324_03850)	790066..790533	-	468	WP_208953667.1	universal stress protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10326.15 Da
• Isoelectric Point: 10.4070

>T125766 WP_208958898.1 NZ_CP040421:786629-786895 [Dolosigranulum pigrum]
MSYQLMLSNKARKQLKKLDPPVAEMIIRWLKANVDGVDNPRSHGKALTGEYKDLWRYRVGNYRIICDVRDRELIILALAV
GHRKDIYK

Nucleotide

• Length: 267 bp

>T125766 NZ_CP040421:786629-786895 [Dolosigranulum pigrum]
ATGAGCTACCAGTTAATGTTAAGCAACAAAGCTAGAAAGCAGCTTAAAAAGTTAGATCCTCCCGTAGCTGAGATGATTAT
ACGGTGGTTGAAGGCTAATGTGGATGGTGTAGATAACCCTAGAAGTCATGGTAAGGCACTGACAGGGGAATATAAAGACT
TATGGCGTTATCGTGTAGGGAATTATCGTATTATTTGTGATGTGAGAGATAGAGAACTAATTATATTAGCATTAGCAGTT
GGACATCGAAAAGATATTTACAAGTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8435.48 Da
• Isoelectric Point: 3.9947

>AT125766 WP_208958897.1 NZ_CP040421:786405-786632 [Dolosigranulum pigrum]
MTIVSVRLNKEEEQAINGYASLTGQPVSQLFKQALIREIEDQLDYKVGIKALAEHEDDPQTFTLEDMADELGINL

Nucleotide

• Length: 228 bp

>AT125766 NZ_CP040421:786405-786632 [Dolosigranulum pigrum]
ATGACAATTGTATCTGTACGACTAAATAAAGAAGAAGAGCAAGCAATTAACGGATATGCCTCATTGACAGGTCAACCGGT
ATCACAATTATTTAAGCAAGCGTTGATTAGAGAGATTGAAGATCAACTAGACTACAAGGTGGGGATTAAAGCGTTAGCTG
AGCACGAGGATGACCCTCAGACATTTACCTTAGAGGATATGGCAGATGAGTTAGGAATTAATTTATGA