Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 800777..801267 Replicon chromosome
Accession NZ_CP040419
Organism Dolosigranulum pigrum strain KPL3069

Toxin (Protein)


Gene name relE Uniprot ID H3NFC0
Locus tag FE326_RS03945 Protein ID WP_004636454.1
Coordinates 801001..801267 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H3NFC1
Locus tag FE326_RS03940 Protein ID WP_004636455.1
Coordinates 800777..801004 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE326_RS03930 (FE326_03855) 795978..797777 + 1800 WP_244325295.1 ABC transporter substrate-binding protein -
FE326_RS03935 (FE326_03860) 797892..800444 - 2553 WP_208954642.1 transglycosylase domain-containing protein -
FE326_RS03940 (FE326_03865) 800777..801004 + 228 WP_004636455.1 DUF6290 family protein Antitoxin
FE326_RS03945 (FE326_03870) 801001..801267 + 267 WP_004636454.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FE326_RS03950 (FE326_03875) 801379..802344 - 966 WP_111950672.1 rhodanese-related sulfurtransferase -
FE326_RS03955 (FE326_03880) 802480..804285 - 1806 WP_208954643.1 M3 family oligoendopeptidase -
FE326_RS03960 (FE326_03885) 804439..804906 - 468 WP_208953667.1 universal stress protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10367.24 Da        Isoelectric Point: 10.5009

>T125764 WP_004636454.1 NZ_CP040419:801001-801267 [Dolosigranulum pigrum]
MSYQLMLSNKARKQLKKLDPPVAEMIIRWLKANVDGVDNPRKHGKALTGEYKDLWRYRVGNYRIICDVRDRELIILALAV
GHRKDIYK

Download         Length: 267 bp

>T125764 NZ_CP040419:801001-801267 [Dolosigranulum pigrum]
ATGAGCTACCAGTTAATGTTAAGCAACAAAGCTAGAAAGCAACTTAAAAAGTTAGACCCTCCCGTAGCTGAGATGATTAT
ACGGTGGTTGAAAGCTAATGTGGATGGTGTAGATAATCCTAGAAAGCATGGTAAGGCACTGACAGGGGAATATAAAGACT
TATGGCGTTATCGTGTAGGGAATTATCGTATTATTTGTGATGTGAGAGATAGAGAACTAATTATATTAGCATTAGCAGTT
GGACATCGAAAAGATATTTACAAGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8473.61 Da        Isoelectric Point: 3.9947

>AT125764 WP_004636455.1 NZ_CP040419:800777-801004 [Dolosigranulum pigrum]
MAIVSVRLNKEEEQVINGYALLTGQPISQLFKQALIREIEDQLDYKVGIKALAEHEDDPQTFTLEDMADELGINL

Download         Length: 228 bp

>AT125764 NZ_CP040419:800777-801004 [Dolosigranulum pigrum]
ATGGCAATTGTATCTGTACGACTGAATAAAGAAGAAGAGCAAGTAATTAATGGATATGCCTTATTGACAGGTCAACCGAT
ATCACAATTATTTAAGCAAGCGTTGATTAGAGAGATTGAAGATCAACTAGACTACAAGGTGGGGATTAAAGCGTTAGCTG
AGCACGAGGATGACCCTCAGACATTTACCTTAGAGGATATGGCAGATGAGTTAGGAATTAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S8KMK3

Antitoxin

Source ID Structure
AlphaFold DB A0A1S8KLU2

References