Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 738749..739239 Replicon chromosome
Accession NZ_CP040418
Organism Dolosigranulum pigrum strain KPL3070

Toxin (Protein)


Gene name relE Uniprot ID H3NFC0
Locus tag FE327_RS03530 Protein ID WP_004636454.1
Coordinates 738973..739239 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H3NFC1
Locus tag FE327_RS03525 Protein ID WP_004636455.1
Coordinates 738749..738976 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE327_RS03515 (FE327_03490) 733932..735785 + 1854 WP_208968971.1 ABC transporter substrate-binding protein -
FE327_RS03520 (FE327_03495) 735862..738414 - 2553 WP_208966685.1 transglycosylase domain-containing protein -
FE327_RS03525 (FE327_03500) 738749..738976 + 228 WP_004636455.1 DUF6290 family protein Antitoxin
FE327_RS03530 (FE327_03505) 738973..739239 + 267 WP_004636454.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FE327_RS03535 (FE327_03510) 739352..740317 - 966 WP_004636453.1 rhodanese-related sulfurtransferase -
FE327_RS03540 (FE327_03515) 740452..742257 - 1806 WP_208966686.1 M3 family oligoendopeptidase -
FE327_RS03545 (FE327_03520) 742412..742879 - 468 WP_111951578.1 universal stress protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10367.24 Da        Isoelectric Point: 10.5009

>T125763 WP_004636454.1 NZ_CP040418:738973-739239 [Dolosigranulum pigrum]
MSYQLMLSNKARKQLKKLDPPVAEMIIRWLKANVDGVDNPRKHGKALTGEYKDLWRYRVGNYRIICDVRDRELIILALAV
GHRKDIYK

Download         Length: 267 bp

>T125763 NZ_CP040418:738973-739239 [Dolosigranulum pigrum]
ATGAGCTACCAGTTAATGTTAAGCAACAAAGCTAGAAAGCAACTTAAAAAGTTAGACCCTCCCGTAGCTGAGATGATTAT
ACGGTGGTTGAAAGCTAATGTGGATGGTGTAGATAATCCTAGAAAGCATGGTAAGGCACTGACAGGGGAATATAAAGATT
TATGGCGTTATCGTGTAGGGAATTATCGTATTATTTGTGATGTGAGAGATAGAGAACTAATTATATTAGCATTAGCAGTT
GGACATCGAAAAGATATTTACAAGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8473.61 Da        Isoelectric Point: 3.9947

>AT125763 WP_004636455.1 NZ_CP040418:738749-738976 [Dolosigranulum pigrum]
MAIVSVRLNKEEEQVINGYALLTGQPISQLFKQALIREIEDQLDYKVGIKALAEHEDDPQTFTLEDMADELGINL

Download         Length: 228 bp

>AT125763 NZ_CP040418:738749-738976 [Dolosigranulum pigrum]
ATGGCAATTGTATCTGTACGACTGAATAAAGAAGAAGAGCAAGTAATTAATGGATATGCCTTATTGACAGGTCAACCGAT
ATCACAATTATTTAAGCAAGCGTTGATTAGAGAGATTGAAGATCAACTAGACTACAAGGTGGGGATTAAAGCGTTAGCTG
AGCACGAGGATGACCCTCAGACATTTACCTTAGAGGATATGGCAGATGAGTTAGGAATTAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S8KMK3

Antitoxin

Source ID Structure
AlphaFold DB A0A1S8KLU2

References