Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 804123..804613 Replicon chromosome
Accession NZ_CP040414
Organism Dolosigranulum pigrum strain KPL3090

Toxin (Protein)


Gene name relE Uniprot ID H3NFC0
Locus tag FE331_RS03965 Protein ID WP_004636454.1
Coordinates 804347..804613 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H3NFC1
Locus tag FE331_RS03960 Protein ID WP_004636455.1
Coordinates 804123..804350 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE331_RS03950 (FE331_03905) 799306..801159 + 1854 WP_208967995.1 oligopeptide ABC transporter substrate-binding protein -
FE331_RS03955 (FE331_03910) 801236..803788 - 2553 WP_208967996.1 transglycosylase domain-containing protein -
FE331_RS03960 (FE331_03915) 804123..804350 + 228 WP_004636455.1 DUF6290 family protein Antitoxin
FE331_RS03965 (FE331_03920) 804347..804613 + 267 WP_004636454.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FE331_RS03970 (FE331_03925) 804724..805689 - 966 WP_004636453.1 rhodanese-related sulfurtransferase -
FE331_RS03975 (FE331_03930) 805825..807630 - 1806 WP_208967997.1 M3 family oligoendopeptidase -
FE331_RS03980 (FE331_03935) 807784..808251 - 468 WP_077862252.1 universal stress protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10367.24 Da        Isoelectric Point: 10.5009

>T125760 WP_004636454.1 NZ_CP040414:804347-804613 [Dolosigranulum pigrum]
MSYQLMLSNKARKQLKKLDPPVAEMIIRWLKANVDGVDNPRKHGKALTGEYKDLWRYRVGNYRIICDVRDRELIILALAV
GHRKDIYK

Download         Length: 267 bp

>T125760 NZ_CP040414:804347-804613 [Dolosigranulum pigrum]
ATGAGCTACCAGTTAATGTTAAGCAACAAAGCTAGAAAGCAACTTAAAAAGTTAGACCCTCCCGTAGCTGAGATGATTAT
ACGGTGGTTGAAAGCTAATGTGGATGGTGTAGATAATCCTAGAAAGCATGGTAAGGCACTGACAGGGGAATATAAAGACT
TATGGCGTTATCGTGTAGGGAATTATCGTATTATTTGTGATGTGAGAGATAGAGAACTAATTATATTAGCATTAGCAGTT
GGACATCGAAAAGATATTTACAAGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8473.61 Da        Isoelectric Point: 3.9947

>AT125760 WP_004636455.1 NZ_CP040414:804123-804350 [Dolosigranulum pigrum]
MAIVSVRLNKEEEQVINGYALLTGQPISQLFKQALIREIEDQLDYKVGIKALAEHEDDPQTFTLEDMADELGINL

Download         Length: 228 bp

>AT125760 NZ_CP040414:804123-804350 [Dolosigranulum pigrum]
ATGGCAATTGTATCTGTACGACTGAATAAAGAAGAAGAGCAAGTAATTAATGGATATGCCTTATTGACAGGTCAACCGAT
ATCACAATTATTTAAGCAAGCGTTGATTAGAGAGATTGAAGATCAACTAGACTACAAGGTGGGGATTAAAGCGTTAGCTG
AGCACGAGGATGACCCTCAGACATTTACCTTAGAGGATATGGCAGATGAGTTAGGAATTAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S8KMK3

Antitoxin

Source ID Structure
AlphaFold DB A0A1S8KLU2

References