Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 743267..743757 Replicon chromosome
Accession NZ_CP040413
Organism Dolosigranulum pigrum strain KPL3246

Toxin (Protein)


Gene name relE Uniprot ID H3NFC0
Locus tag FE332_RS03515 Protein ID WP_004636454.1
Coordinates 743491..743757 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H3NFC1
Locus tag FE332_RS03510 Protein ID WP_004636455.1
Coordinates 743267..743494 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE332_RS03500 (FE332_03485) 738450..740303 + 1854 WP_208969366.1 oligopeptide ABC transporter substrate-binding protein -
FE332_RS03505 (FE332_03490) 740380..742932 - 2553 WP_208969367.1 transglycosylase domain-containing protein -
FE332_RS03510 (FE332_03495) 743267..743494 + 228 WP_004636455.1 DUF6290 family protein Antitoxin
FE332_RS03515 (FE332_03500) 743491..743757 + 267 WP_004636454.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FE332_RS03520 (FE332_03505) 743868..744833 - 966 WP_111950672.1 rhodanese-related sulfurtransferase -
FE332_RS03525 (FE332_03510) 744969..746774 - 1806 WP_208965906.1 M3 family oligoendopeptidase -
FE332_RS03530 (FE332_03515) 746929..747396 - 468 WP_111951578.1 universal stress protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10367.24 Da        Isoelectric Point: 10.5009

>T125759 WP_004636454.1 NZ_CP040413:743491-743757 [Dolosigranulum pigrum]
MSYQLMLSNKARKQLKKLDPPVAEMIIRWLKANVDGVDNPRKHGKALTGEYKDLWRYRVGNYRIICDVRDRELIILALAV
GHRKDIYK

Download         Length: 267 bp

>T125759 NZ_CP040413:743491-743757 [Dolosigranulum pigrum]
ATGAGCTACCAGTTAATGTTAAGCAACAAAGCTAGAAAGCAACTTAAAAAGTTAGACCCTCCCGTAGCTGAGATGATTAT
ACGGTGGTTGAAAGCTAATGTGGATGGTGTAGATAATCCTAGAAAGCATGGTAAGGCACTGACAGGGGAATATAAAGACT
TATGGCGTTATCGTGTAGGGAATTATCGTATTATTTGTGATGTGAGAGATAGAGAACTAATTATATTAGCATTAGCAGTT
GGACATCGAAAAGATATTTACAAGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8473.61 Da        Isoelectric Point: 3.9947

>AT125759 WP_004636455.1 NZ_CP040413:743267-743494 [Dolosigranulum pigrum]
MAIVSVRLNKEEEQVINGYALLTGQPISQLFKQALIREIEDQLDYKVGIKALAEHEDDPQTFTLEDMADELGINL

Download         Length: 228 bp

>AT125759 NZ_CP040413:743267-743494 [Dolosigranulum pigrum]
ATGGCAATTGTATCTGTACGACTGAATAAAGAAGAAGAGCAAGTAATTAATGGATATGCCTTATTGACAGGTCAACCGAT
ATCACAATTATTTAAGCAAGCGTTGATTAGAGAGATTGAAGATCAACTAGACTACAAGGTGGGGATTAAAGCGTTAGCTG
AGCACGAGGATGACCCTCAGACATTTACCTTAGAGGATATGGCAGATGAGTTAGGAATTAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S8KMK3

Antitoxin

Source ID Structure
AlphaFold DB A0A1S8KLU2

References