Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 721347..721837 Replicon chromosome
Accession NZ_CP040412
Organism Dolosigranulum pigrum strain KPL3250

Toxin (Protein)


Gene name relE Uniprot ID H3NFC0
Locus tag FE333_RS03425 Protein ID WP_004636454.1
Coordinates 721571..721837 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H3NFC1
Locus tag FE333_RS03420 Protein ID WP_004636455.1
Coordinates 721347..721574 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE333_RS03410 (FE333_03395) 716533..718383 + 1851 WP_244359824.1 ABC transporter substrate-binding protein -
FE333_RS03415 (FE333_03400) 718460..721012 - 2553 WP_208957579.1 transglycosylase domain-containing protein -
FE333_RS03420 (FE333_03405) 721347..721574 + 228 WP_004636455.1 DUF6290 family protein Antitoxin
FE333_RS03425 (FE333_03410) 721571..721837 + 267 WP_004636454.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FE333_RS03430 (FE333_03415) 721950..722915 - 966 WP_208957580.1 rhodanese-related sulfurtransferase -
FE333_RS03435 (FE333_03420) 723051..724856 - 1806 WP_208957581.1 M3 family oligoendopeptidase -
FE333_RS03440 (FE333_03425) 725011..725478 - 468 WP_111951578.1 universal stress protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10367.24 Da        Isoelectric Point: 10.5009

>T125758 WP_004636454.1 NZ_CP040412:721571-721837 [Dolosigranulum pigrum]
MSYQLMLSNKARKQLKKLDPPVAEMIIRWLKANVDGVDNPRKHGKALTGEYKDLWRYRVGNYRIICDVRDRELIILALAV
GHRKDIYK

Download         Length: 267 bp

>T125758 NZ_CP040412:721571-721837 [Dolosigranulum pigrum]
ATGAGCTACCAGTTAATGTTAAGCAACAAAGCTAGAAAGCAACTTAAAAAGTTAGACCCTCCCGTAGCTGAGATGATTAT
ACGGTGGTTGAAAGCTAATGTGGATGGTGTAGATAATCCTAGAAAGCATGGTAAGGCACTGACAGGGGAATATAAAGATT
TATGGCGTTATCGTGTAGGGAATTATCGTATTATTTGTGATGTGAGAGATAGAGAACTAATTATATTAGCATTAGCAGTT
GGACATCGAAAAGATATTTACAAGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8473.61 Da        Isoelectric Point: 3.9947

>AT125758 WP_004636455.1 NZ_CP040412:721347-721574 [Dolosigranulum pigrum]
MAIVSVRLNKEEEQVINGYALLTGQPISQLFKQALIREIEDQLDYKVGIKALAEHEDDPQTFTLEDMADELGINL

Download         Length: 228 bp

>AT125758 NZ_CP040412:721347-721574 [Dolosigranulum pigrum]
ATGGCAATTGTATCTGTACGACTGAATAAAGAAGAAGAGCAAGTAATTAATGGATATGCCTTATTGACAGGTCAACCGAT
ATCACAATTATTTAAGCAAGCGTTGATTAGAGAGATTGAAGATCAACTAGACTACAAGGTGGGGATTAAAGCGTTAGCTG
AGCACGAGGATGACCCTCAGACATTTACCTTAGAGGATATGGCAGATGAGTTAGGAATTAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S8KMK3

Antitoxin

Source ID Structure
AlphaFold DB A0A1S8KLU2

References