Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2555257..2556101 Replicon chromosome
Accession NZ_CP040397
Organism Escherichia coli strain BA22372

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag FEV15_RS12340 Protein ID WP_000854686.1
Coordinates 2555718..2556101 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag FEV15_RS12335 Protein ID WP_001285602.1
Coordinates 2555257..2555637 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEV15_RS12295 2551505..2551960 + 456 WP_000581506.1 hypothetical protein -
FEV15_RS12300 2552061..2552269 + 209 Protein_2352 DUF905 domain-containing protein -
FEV15_RS12310 2552370..2553191 + 822 WP_001761104.1 DUF945 domain-containing protein -
FEV15_RS12315 2553283..2553768 + 486 WP_000214307.1 antirestriction protein -
FEV15_RS12320 2553784..2554260 + 477 WP_001186726.1 RadC family protein -
FEV15_RS12325 2554323..2554544 + 222 WP_000692298.1 DUF987 domain-containing protein -
FEV15_RS12330 2554563..2555246 + 684 WP_000086768.1 hypothetical protein -
FEV15_RS12335 2555257..2555637 + 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FEV15_RS12340 2555718..2556101 + 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
FEV15_RS12345 2556098..2556586 + 489 WP_032180032.1 hypothetical protein -
FEV15_RS12350 2556603..2556800 + 198 WP_000839253.1 DUF957 domain-containing protein -
FEV15_RS12355 2556885..2557726 + 842 Protein_2362 DUF4942 domain-containing protein -
FEV15_RS12365 2558197..2559135 + 939 WP_000351311.1 glyoxylate/hydroxypyruvate reductase GhrA -
FEV15_RS12370 2559190..2559927 + 738 WP_000283664.1 zinc-binding phosphatase -
FEV15_RS12375 2559951..2560505 + 555 WP_001001902.1 molecular chaperone YcdY -
FEV15_RS12380 2560607..2561098 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaCMY-2 csgG / csgF / csgE / csgD / csgB / csgA / csgC 2509076..2566664 57588


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T125732 WP_000854686.1 NZ_CP040397:2555718-2556101 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T125732 NZ_CP040397:2555718-2556101 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT125732 WP_001285602.1 NZ_CP040397:2555257-2555637 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT125732 NZ_CP040397:2555257-2555637 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References