125726

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 3457773..3458401 Replicon chromosome
Accession NZ_CP040396
Organism Paenibacillus sp. HB172198

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag E6C60_RS16240 Protein ID WP_138227849.1
Coordinates 3457773..3458123 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag E6C60_RS16245 Protein ID WP_175415338.1
Coordinates 3458129..3458401 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E6C60_RS16220 3453703..3454185 - 483 WP_175415432.1 SprT family protein -
E6C60_RS16225 3454327..3454677 + 351 WP_138226793.1 hydrolase/acyltransferase -
E6C60_RS16230 3454808..3454936 + 129 WP_138226794.1 cortex morphogenetic protein CmpA -
E6C60_RS16235 3455068..3457287 - 2220 WP_138226795.1 RNA-binding transcriptional accessory protein -
E6C60_RS21015 3457533..3457709 + 177 WP_175415337.1 hypothetical protein -
E6C60_RS16240 3457773..3458123 - 351 WP_138227849.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E6C60_RS16245 3458129..3458401 - 273 WP_175415338.1 ribbon-helix-helix protein, CopG family Antitoxin
E6C60_RS16250 3458638..3459813 - 1176 WP_138226797.1 alanine racemase -
E6C60_RS16255 3460092..3461201 - 1110 WP_138227850.1 outer membrane lipoprotein carrier protein LolA -
E6C60_RS16260 3461309..3461977 - 669 WP_138226798.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12735.58 Da        Isoelectric Point: 4.8265

>T125726 WP_138227849.1 NZ_CP040396:c3458123-3457773 [Paenibacillus sp. HB172198]
VIVKRGDVFFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAASHGFDRDSVILLEQI
RTIDKQRLTDKITHLDDETMSKVDDSLQISLGLIDF

Download         Length: 351 bp

>T125726 NZ_CP040396:c3458123-3457773 [Paenibacillus sp. HB172198]
GTGATCGTAAAACGCGGCGACGTATTTTTTGCGGATCTTTCACCCGTTGTGGGTTCAGAGCAGGGTGGTGTCAGGCCGGT
TCTGATTATTCAGAATGATATCGGAAACCGGTTCAGTCCAACGGTCATTGTAGCAGCAATTACAGCACAGATTCAAAAAG
CAAAGCTTCCGACTCACGTCGAAATCGACGCGGCGTCCCATGGCTTTGACCGGGATTCCGTGATTCTGCTGGAGCAGATC
CGGACGATTGACAAGCAGCGCCTGACGGATAAGATTACCCATCTGGATGATGAAACCATGAGCAAGGTGGATGATTCCCT
GCAGATTAGTCTCGGTTTGATTGATTTTTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10496.05 Da        Isoelectric Point: 6.7270

>AT125726 WP_175415338.1 NZ_CP040396:c3458401-3458129 [Paenibacillus sp. HB172198]
MQNTKRIMISLPDHLLQEVDGIAQLENSNRSELIRQAMKLYLHERKKRYIRESMQRGYMEMAKINLTMASEAFHAEEDAD
STLDRLVSGV

Download         Length: 273 bp

>AT125726 NZ_CP040396:c3458401-3458129 [Paenibacillus sp. HB172198]
ATGCAGAACACCAAACGAATCATGATCAGTCTACCAGATCATCTTTTGCAGGAAGTGGATGGGATCGCTCAGCTGGAAAA
TTCCAACCGCAGTGAATTGATCAGGCAGGCCATGAAGCTGTATTTGCACGAGCGGAAGAAGCGCTATATCCGTGAGTCAA
TGCAGAGAGGTTATATGGAGATGGCCAAGATTAACCTCACCATGGCGTCCGAGGCGTTTCACGCGGAGGAAGATGCAGAC
AGCACTCTGGACCGCTTAGTTAGCGGGGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References