Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 4857306..4857951 Replicon chromosome
Accession NZ_CP040392
Organism Kosakonia radicincitans strain DSM 107547

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FEI17_RS23080 Protein ID WP_035886605.1
Coordinates 4857306..4857488 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FEI17_RS23085 Protein ID WP_035943124.1
Coordinates 4857514..4857951 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEI17_RS23055 4852380..4853333 - 954 WP_035886600.1 helix-turn-helix transcriptional regulator -
FEI17_RS23060 4853461..4854366 - 906 WP_149289194.1 LysR family transcriptional regulator -
FEI17_RS23065 4854453..4855238 + 786 WP_071920165.1 NAD(P)H-dependent oxidoreductase -
FEI17_RS23070 4855430..4856002 + 573 WP_007372977.1 TetR/AcrR family transcriptional regulator -
FEI17_RS23075 4856069..4857235 + 1167 WP_149289195.1 multidrug effflux MFS transporter -
FEI17_RS23080 4857306..4857488 + 183 WP_035886605.1 type II toxin-antitoxin system HicA family toxin Toxin
FEI17_RS23085 4857514..4857951 + 438 WP_035943124.1 hypothetical protein Antitoxin
FEI17_RS23090 4857948..4858841 - 894 WP_149289196.1 MurR/RpiR family transcriptional regulator -
FEI17_RS23095 4858854..4859801 - 948 WP_149289197.1 iron-siderophore ABC transporter substrate-binding protein -
FEI17_RS23100 4859816..4860868 - 1053 WP_007372972.1 iron ABC transporter permease -
FEI17_RS23105 4860865..4861887 - 1023 WP_149289198.1 iron ABC transporter permease -
FEI17_RS23110 4861884..4862708 - 825 WP_007372970.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6770.97 Da        Isoelectric Point: 11.0174

>T125724 WP_035886605.1 NZ_CP040392:4857306-4857488 [Kosakonia radicincitans]
MKYSEFRKWLLSQGAELTKAPGGGSHFKVRLNGRASVFPFHGSKEIPEPLRKKIMKDLGL

Download         Length: 183 bp

>T125724 NZ_CP040392:4857306-4857488 [Kosakonia radicincitans]
ATGAAATACAGCGAGTTCAGAAAGTGGTTGTTATCTCAGGGAGCGGAGCTAACCAAAGCTCCAGGTGGAGGAAGCCATTT
TAAAGTCAGGCTTAATGGTAGGGCATCGGTTTTCCCTTTTCATGGTTCGAAAGAGATTCCTGAGCCGTTGAGGAAAAAGA
TTATGAAGGACTTAGGCCTGTAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 15953.41 Da        Isoelectric Point: 5.5739

>AT125724 WP_035943124.1 NZ_CP040392:4857514-4857951 [Kosakonia radicincitans]
MFNYPVHIERDDATGQFVVSCRDLPLMNSVGDTLDEALLQSIDGIVVAIAIEIDERRPIPAASAPLKGEYIVSLPVLVAM
KAALHNAMIETGTRKAELARKLGQKGPQIDRLLDVEHSSKVETVELALHQLNRQIDLTITPQHRA

Download         Length: 438 bp

>AT125724 NZ_CP040392:4857514-4857951 [Kosakonia radicincitans]
ATGTTTAATTATCCCGTCCACATTGAACGAGACGATGCTACAGGTCAGTTCGTGGTCTCATGCCGCGATCTACCGCTCAT
GAACTCCGTTGGCGATACGCTTGATGAGGCTTTACTGCAGTCGATTGATGGGATTGTTGTTGCGATTGCTATCGAAATTG
ACGAGCGGCGTCCAATCCCGGCGGCAAGCGCGCCGCTAAAAGGCGAATACATCGTATCGCTGCCCGTACTCGTAGCCATG
AAAGCCGCACTGCATAACGCCATGATCGAAACCGGGACGCGAAAAGCTGAGCTGGCAAGAAAGCTGGGACAGAAAGGGCC
GCAAATTGACCGCTTGCTCGATGTGGAGCACTCATCGAAGGTGGAAACGGTTGAACTGGCGCTACATCAGTTAAATCGAC
AGATTGATCTGACCATTACGCCGCAGCACAGAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References