Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4240284..4240900 Replicon chromosome
Accession NZ_CP040392
Organism Kosakonia radicincitans strain DSM 107547

Toxin (Protein)


Gene name Hha Uniprot ID A0A1C4FBY4
Locus tag FEI17_RS20135 Protein ID WP_007373583.1
Coordinates 4240682..4240900 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A6M5CWA9
Locus tag FEI17_RS20130 Protein ID WP_007373584.1
Coordinates 4240284..4240658 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEI17_RS20120 4235405..4236598 + 1194 WP_007373586.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FEI17_RS20125 4236621..4239770 + 3150 WP_007373585.1 multidrug efflux RND transporter permease subunit -
FEI17_RS20130 4240284..4240658 + 375 WP_007373584.1 Hha toxicity modulator TomB Antitoxin
FEI17_RS20135 4240682..4240900 + 219 WP_007373583.1 hemolysin expression modulator Hha Toxin
FEI17_RS20140 4240966..4241526 + 561 WP_007373582.1 maltose O-acetyltransferase -
FEI17_RS20145 4241627..4242106 + 480 WP_035887316.1 YlaC family protein -
FEI17_RS20150 4242072..4243517 - 1446 WP_007373580.1 PLP-dependent aminotransferase family protein -
FEI17_RS20155 4243615..4244316 + 702 WP_035887312.1 GNAT family N-acetyltransferase -
FEI17_RS20160 4244313..4244453 - 141 WP_007373577.1 type B 50S ribosomal protein L36 -
FEI17_RS20165 4244457..4244717 - 261 WP_072438211.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8637.05 Da        Isoelectric Point: 7.9893

>T125722 WP_007373583.1 NZ_CP040392:4240682-4240900 [Kosakonia radicincitans]
MSEKPLTKVDYLMRLRRCQTIDTLERVIEKNKYELPDEELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T125722 NZ_CP040392:4240682-4240900 [Kosakonia radicincitans]
ATGTCCGAAAAACCATTAACAAAAGTTGATTATTTGATGCGTCTCAGACGTTGTCAGACAATTGATACCCTTGAACGTGT
AATTGAAAAAAATAAATACGAACTTCCGGATGAGGAACTCGCGGTGTTTTATTCAGCAGCCGATCATCGCCTGGCAGAAC
TGACCATGAATAAGCTGTATGACAAAATCCCCTCCTCCGTGTGGAAATTTGTACGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14567.42 Da        Isoelectric Point: 5.8339

>AT125722 WP_007373584.1 NZ_CP040392:4240284-4240658 [Kosakonia radicincitans]
MDEYSPKRHDIAQLKFLCETLYHDCLVNLEESHHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTHDLQKWRKTGNKLFRCFVNVSKANPVSHSC

Download         Length: 375 bp

>AT125722 NZ_CP040392:4240284-4240658 [Kosakonia radicincitans]
ATGGACGAATACTCGCCAAAAAGGCATGATATCGCGCAGCTCAAATTTCTCTGCGAAACACTGTACCATGACTGCCTTGT
TAATCTCGAAGAGAGCCATCATGGGTGGGTTAACGATCCTACATCAGCGGTGAACTTGCAGTTAAATGAGCTGATAGAAC
ACATAGCGACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAACTGATTGAACAGATAGACGAATATCTT
GACGATACGTTTATGTTGTTCAGTAGCTATGGCATAAATACACATGACTTACAGAAATGGCGCAAAACAGGTAACAAGCT
GTTCCGCTGCTTCGTCAATGTAAGCAAGGCTAATCCTGTTAGCCACTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C4FBY4

Antitoxin

Source ID Structure
AlphaFold DB A0A6M5CWA9

References