Detailed information of TA system TA125721

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 4010154..4010711
• Replicon: chromosome
• Accession: NZ_CP040392
• Organism: Kosakonia radicincitans strain DSM 107547

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FEI17_RS19030
• Protein ID: WP_072438369.1
• Coordinates: 4010436..4010711 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FEI17_RS19025
• Protein ID: WP_071920458.1
• Coordinates: 4010154..4010432 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEI17_RS19010	4006121..4007116	-	996	WP_007373782.1	ABC transporter permease	-
FEI17_RS19015	4007113..4008615	-	1503	WP_149289024.1	sugar ABC transporter ATP-binding protein	-
FEI17_RS19020	4008778..4009866	+	1089	WP_144134406.1	oxidoreductase	-
FEI17_RS19025	4010154..4010432	+	279	WP_071920458.1	CopG family ribbon-helix-helix protein	Antitoxin
FEI17_RS19030	4010436..4010711	+	276	WP_072438369.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FEI17_RS19035	4010786..4011373	-	588	WP_007373776.1	TetR/AcrR family transcriptional regulator	-
FEI17_RS19040	4011485..4012228	+	744	WP_007373775.1	SDR family oxidoreductase	-
FEI17_RS19045	4012248..4012445	-	198	WP_000460621.1	YbdD/YjiX family protein	-
FEI17_RS19050	4012494..4014599	-	2106	WP_035886031.1	carbon starvation protein CstA	-
FEI17_RS19055	4014767..4015180	-	414	WP_035886032.1	proofreading thioesterase EntH	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-44)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10849.63 Da
• Isoelectric Point: 5.1100

>T125721 WP_072438369.1 NZ_CP040392:4010436-4010711 [Kosakonia radicincitans]
MQLEWTRLALQDVERLSKFLFIQNPEAARKVVIMLADAPEMLLLHPQIGPPDESWYPREIRSLFVGSYEMIYELTDSHII
ILRIWHTKEDR

Nucleotide

• Length: 276 bp

>T125721 NZ_CP040392:4010436-4010711 [Kosakonia radicincitans]
ATGCAGTTAGAATGGACGCGACTCGCTCTTCAGGATGTAGAGAGACTGTCAAAATTCCTGTTTATCCAAAACCCTGAAGC
CGCCCGCAAAGTTGTCATCATGTTGGCTGACGCCCCTGAAATGCTCTTGCTCCACCCACAAATAGGCCCGCCGGATGAAA
GCTGGTATCCGCGCGAAATCCGTTCTTTGTTTGTTGGCAGTTATGAAATGATTTACGAACTGACGGACAGCCATATCATC
ATCCTGCGAATCTGGCATACAAAAGAAGACCGTTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10078.65 Da
• Isoelectric Point: 8.6586

>AT125721 WP_071920458.1 NZ_CP040392:4010154-4010432 [Kosakonia radicincitans]
MSGTKVLTAHVPIELADKVDLLAESSERSRGWIIKRALAEYIERAELRQAMIQQGLDAVERGETVSHAEAATWLKSLGTV
NPMPLPGVKKRG

Nucleotide

• Length: 279 bp

>AT125721 NZ_CP040392:4010154-4010432 [Kosakonia radicincitans]
ATGTCTGGGACGAAAGTACTGACAGCGCATGTACCTATTGAACTCGCCGATAAAGTCGATTTACTTGCCGAAAGCAGCGA
ACGCTCGCGGGGCTGGATTATCAAACGTGCGCTCGCGGAATATATTGAGCGTGCAGAATTACGCCAGGCCATGATCCAGC
AAGGCCTGGATGCCGTTGAACGCGGTGAAACCGTCAGTCATGCAGAAGCGGCGACCTGGCTTAAAAGTCTGGGGACGGTT
AATCCAATGCCGCTGCCAGGCGTTAAAAAACGGGGATGA