Detailed information of TA system TA125706

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4787167..4787935
• Replicon: chromosome
• Accession: NZ_CP040391
• Organism: Klebsiella pneumoniae strain LSH-KPN25

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: FEF28_RS23275
• Protein ID: WP_075666967.1
• Coordinates: 4787167..4787553 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: FEF28_RS23280
• Protein ID: WP_170932194.1
• Coordinates: 4787609..4787935 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEF28_RS23245	4782524..4782862	+	339	WP_064449948.1	hypothetical protein	-
FEF28_RS23250	4782865..4783344	+	480	WP_002887049.1	type VI secretion system tube protein Hcp	-
FEF28_RS23255	4783536..4783859	-	324	Protein_4630	hypothetical protein	-
FEF28_RS23260	4783878..4784989	-	1112	Protein_4631	IS3 family transposase	-
FEF28_RS23265	4785305..4786102	-	798	WP_064387500.1	helix-turn-helix transcriptional regulator	-
FEF28_RS23270	4786245..4787090	-	846	WP_075666968.1	DUF4942 domain-containing protein	-
FEF28_RS23275	4787167..4787553	-	387	WP_075666967.1	TA system toxin CbtA family protein	Toxin
FEF28_RS23280	4787609..4787935	-	327	WP_170932194.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FEF28_RS23285	4787993..4788214	-	222	WP_075666965.1	DUF987 domain-containing protein	-
FEF28_RS23290	4788228..4788707	-	480	WP_075666964.1	DNA repair protein RadC	-
FEF28_RS23295	4788719..4789162	-	444	WP_075666963.1	antirestriction protein	-
FEF28_RS23300	4789242..4789490	-	249	WP_044347584.1	DUF905 domain-containing protein	-
FEF28_RS23305	4789496..4790320	-	825	WP_075666962.1	DUF945 domain-containing protein	-
FEF28_RS23310	4790692..4791633	-	942	WP_075666961.1	hypothetical protein	-
FEF28_RS23315	4792197..4792817	+	621	WP_157261986.1	inovirus Gp2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4782865..4823879	41014

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (7-110)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14414.58 Da
• Isoelectric Point: 7.3222

>T125706 WP_075666967.1 NZ_CP040391:c4787553-4787167 [Klebsiella pneumoniae]
MQTTLPFMRAVSSCPSPVDVWQTLLTCLLEHHYGLTLNDTPFSDEQVIQQHIDAGISLADALNFIVEKYELVRTDRPGFS
IMEQSPFITPIDILRARKATGLMNRGTYKEVTAITRGLHRQVSTPGKR

Nucleotide

• Length: 387 bp

>T125706 NZ_CP040391:c4787553-4787167 [Klebsiella pneumoniae]
ATGCAAACTACATTGCCCTTCATGCGGGCGGTATCGTCATGTCCGTCTCCCGTTGATGTCTGGCAGACCCTGCTGACCTG
CCTGCTGGAACACCACTATGGCCTCACGCTTAACGATACGCCGTTCAGTGATGAACAGGTCATTCAGCAGCATATCGACG
CAGGTATCTCGCTGGCCGATGCCCTGAATTTTATTGTAGAGAAGTACGAACTGGTCCGCACTGACCGGCCAGGTTTCAGC
ATCATGGAGCAGTCTCCGTTTATCACGCCCATAGATATCCTCCGGGCCAGAAAGGCTACGGGGCTGATGAACCGTGGCAC
GTATAAAGAGGTGACGGCCATTACCAGAGGACTGCATCGACAGGTCAGTACTCCCGGCAAACGCTGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12135.87 Da
• Isoelectric Point: 6.9459

>AT125706 WP_170932194.1 NZ_CP040391:c4787935-4787609 [Klebsiella pneumoniae]
ISEPWWGLRRSVSVCFGARLVQEGNRLHYLADRANFNGQFCDADLRHLDQAFPVLMKQLELMLTSGELNPRHQHCVTLYA
KGLTCEADTLGSHGYVYIAIYPTPVATA

Nucleotide

• Length: 327 bp

>AT125706 NZ_CP040391:c4787935-4787609 [Klebsiella pneumoniae]
ATCAGCGAACCCTGGTGGGGGCTCAGACGCAGTGTCTCCGTGTGCTTTGGTGCCCGACTGGTCCAGGAGGGAAACCGCCT
GCATTACCTGGCTGACCGCGCGAATTTTAACGGACAGTTCTGCGATGCGGATTTGCGCCATCTTGACCAGGCCTTCCCGG
TATTGATGAAACAGCTGGAGTTAATGCTCACCAGCGGTGAACTAAATCCCCGTCATCAGCACTGCGTCACGCTGTATGCA
AAAGGTCTGACCTGCGAGGCCGATACGCTCGGTTCGCACGGTTATGTTTATATCGCGATTTATCCCACTCCTGTCGCCAC
GGCATAA