Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pemIK/PRK09812-MazE |
Location | 3551718..3552308 | Replicon | chromosome |
Accession | NZ_CP040363 | ||
Organism | Klebsiella pneumoniae strain R50 |
Toxin (Protein)
Gene name | pemK | Uniprot ID | A0A2L1BXX2 |
Locus tag | FEM43_RS17620 | Protein ID | WP_022615588.1 |
Coordinates | 3551976..3552308 (+) | Length | 111 a.a. |
Antitoxin (Protein)
Gene name | pemI | Uniprot ID | - |
Locus tag | FEM43_RS17615 | Protein ID | WP_117074187.1 |
Coordinates | 3551718..3551975 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FEM43_RS17585 | 3547544..3547786 | - | 243 | WP_069376237.1 | hypothetical protein | - |
FEM43_RS17590 | 3548053..3549801 | + | 1749 | WP_102014240.1 | hypothetical protein | - |
FEM43_RS17595 | 3549855..3550436 | + | 582 | WP_099184326.1 | hypothetical protein | - |
FEM43_RS17600 | 3550719..3551180 | + | 462 | WP_004213450.1 | hypothetical protein | - |
FEM43_RS17605 | 3551177..3551383 | + | 207 | WP_020805021.1 | helix-turn-helix domain-containing protein | - |
FEM43_RS17615 | 3551718..3551975 | + | 258 | WP_117074187.1 | antitoxin | Antitoxin |
FEM43_RS17620 | 3551976..3552308 | + | 333 | WP_022615588.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
FEM43_RS17630 | 3552630..3554066 | + | 1437 | WP_004151469.1 | EmmdR/YeeO family multidrug/toxin efflux MATE transporter | - |
FEM43_RS17640 | 3554432..3555886 | - | 1455 | WP_004148975.1 | AMP nucleosidase | - |
FEM43_RS17645 | 3556016..3556261 | - | 246 | WP_004141189.1 | signal transduction protein PmrD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 11913.80 Da Isoelectric Point: 10.1839
>T125641 WP_022615588.1 NZ_CP040363:3551976-3552308 [Klebsiella pneumoniae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDVVVNEVLARLDAMLS
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDVVVNEVLARLDAMLS
Download Length: 333 bp
>T125641 NZ_CP040363:3551976-3552308 [Klebsiella pneumoniae]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTACTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACCCGACTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGTTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGGACTATC
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGTCGTTGTCAACGAGGTGCTTGCCAGGCTGGATGC
GATGCTGAGTTAA
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTACTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACCCGACTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGTTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGGACTATC
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGTCGTTGTCAACGAGGTGCTTGCCAGGCTGGATGC
GATGCTGAGTTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9426.96 Da Isoelectric Point: 4.4620
>AT125641 WP_117074187.1 NZ_CP040363:3551718-3551975 [Klebsiella pneumoniae]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCVPHAEMSEEDREWIDAPAV
GKEIL
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCVPHAEMSEEDREWIDAPAV
GKEIL
Download Length: 258 bp
>AT125641 NZ_CP040363:3551718-3551975 [Klebsiella pneumoniae]
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGTTCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATTCTGTAA
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGTTCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATTCTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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