Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3951359..3951978 Replicon chromosome
Accession NZ_CP040354
Organism Klebsiella pneumoniae strain P20

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag FEZ11_RS19325 Protein ID WP_002892050.1
Coordinates 3951760..3951978 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag FEZ11_RS19320 Protein ID WP_002892066.1
Coordinates 3951359..3951733 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEZ11_RS19310 (3946511) 3946511..3947704 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FEZ11_RS19315 (3947727) 3947727..3950873 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
FEZ11_RS19320 (3951359) 3951359..3951733 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
FEZ11_RS19325 (3951760) 3951760..3951978 + 219 WP_002892050.1 HHA domain-containing protein Toxin
FEZ11_RS19330 (3952137) 3952137..3952703 + 567 WP_002892030.1 maltose O-acetyltransferase -
FEZ11_RS19335 (3952675) 3952675..3952815 - 141 WP_004147370.1 hypothetical protein -
FEZ11_RS19340 (3952836) 3952836..3953306 + 471 WP_002892026.1 YlaC family protein -
FEZ11_RS19345 (3953313) 3953313..3954770 - 1458 WP_029883993.1 PLP-dependent aminotransferase family protein -
FEZ11_RS19350 (3954871) 3954871..3955569 + 699 WP_002892021.1 GNAT family protein -
FEZ11_RS19355 (3955566) 3955566..3955706 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
FEZ11_RS19360 (3955706) 3955706..3955969 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T125629 WP_002892050.1 NZ_CP040354:3951760-3951978 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T125629 NZ_CP040354:3951760-3951978 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACACTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT125629 WP_002892066.1 NZ_CP040354:3951359-3951733 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT125629 NZ_CP040354:3951359-3951733 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References