Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4713923..4714439 Replicon chromosome
Accession NZ_CP040351
Organism Klebsiella pneumoniae strain P39

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag FEZ16_RS22740 Protein ID WP_004178374.1
Coordinates 4713923..4714207 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FEZ16_RS22745 Protein ID WP_002886901.1
Coordinates 4714197..4714439 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEZ16_RS22715 (FEZ16_22890) 4709319..4709582 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
FEZ16_RS22720 4709712..4709885 + 174 WP_004222159.1 hypothetical protein -
FEZ16_RS22725 (FEZ16_22895) 4709888..4710631 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FEZ16_RS22730 (FEZ16_22900) 4710988..4713126 + 2139 WP_032415880.1 anaerobic ribonucleoside-triphosphate reductase -
FEZ16_RS22735 (FEZ16_22905) 4713455..4713919 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FEZ16_RS22740 (FEZ16_22910) 4713923..4714207 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FEZ16_RS22745 (FEZ16_22915) 4714197..4714439 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FEZ16_RS22750 (FEZ16_22920) 4714517..4716427 - 1911 WP_130974884.1 PRD domain-containing protein -
FEZ16_RS22755 (FEZ16_22925) 4716450..4717604 - 1155 WP_004178372.1 lactonase family protein -
FEZ16_RS22760 (FEZ16_22930) 4717671..4718411 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T125610 WP_004178374.1 NZ_CP040351:c4714207-4713923 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T125610 NZ_CP040351:c4714207-4713923 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT125610 WP_002886901.1 NZ_CP040351:c4714439-4714197 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT125610 NZ_CP040351:c4714439-4714197 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCTGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References