Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 780320..780977 Replicon chromosome
Accession NZ_CP040351
Organism Klebsiella pneumoniae strain P39

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag FEZ16_RS03875 Protein ID WP_002916310.1
Coordinates 780567..780977 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag FEZ16_RS03870 Protein ID WP_002916312.1
Coordinates 780320..780586 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEZ16_RS03845 (FEZ16_03860) 775476..776909 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
FEZ16_RS03850 (FEZ16_03865) 777028..777756 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
FEZ16_RS03855 (FEZ16_03870) 777806..778117 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
FEZ16_RS03860 (FEZ16_03875) 778281..778940 + 660 WP_002916317.1 hemolysin III family protein -
FEZ16_RS03865 (FEZ16_03880) 779091..780074 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
FEZ16_RS03870 (FEZ16_03885) 780320..780586 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
FEZ16_RS03875 (FEZ16_03890) 780567..780977 + 411 WP_002916310.1 protein YgfX Toxin
FEZ16_RS03880 (FEZ16_03895) 780984..781505 - 522 WP_002916308.1 flavodoxin FldB -
FEZ16_RS03885 (FEZ16_03900) 781606..782502 + 897 WP_064153067.1 site-specific tyrosine recombinase XerD -
FEZ16_RS03890 (FEZ16_03905) 782525..783238 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FEZ16_RS03895 (FEZ16_03910) 783244..784977 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T125598 WP_002916310.1 NZ_CP040351:780567-780977 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T125598 NZ_CP040351:780567-780977 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT125598 WP_002916312.1 NZ_CP040351:780320-780586 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT125598 NZ_CP040351:780320-780586 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References