Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 1597087..1598605 Replicon chromosome
Accession NZ_CP040349
Organism Pseudomonas guguanensis strain HMFL31

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag FE254_RS07255 Protein ID WP_024889510.1
Coordinates 1597087..1597995 (-) Length 303 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag FE254_RS07260 Protein ID WP_024889509.1
Coordinates 1597985..1598605 (-) Length 207 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE254_RS07240 (FE254_07305) 1592292..1593722 + 1431 WP_024889513.1 TIGR03752 family integrating conjugative element protein -
FE254_RS07245 (FE254_07310) 1593703..1594134 + 432 WP_024889512.1 TIGR03751 family conjugal transfer lipoprotein -
FE254_RS07250 (FE254_07315) 1594134..1597022 + 2889 WP_286586749.1 conjugative transfer ATPase -
FE254_RS07255 (FE254_07320) 1597087..1597995 - 909 WP_024889510.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
FE254_RS07260 (FE254_07325) 1597985..1598605 - 621 WP_024889509.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
FE254_RS07265 (FE254_07330) 1598767..1599537 + 771 WP_024889508.1 thioredoxin domain-containing protein -
FE254_RS07270 (FE254_07335) 1599728..1600228 + 501 WP_024889507.1 DNA repair protein RadC -
FE254_RS07275 (FE254_07340) 1600330..1600902 + 573 WP_286586751.1 hypothetical protein -
FE254_RS07280 (FE254_07345) 1601035..1601292 + 258 WP_024889505.1 metal-sensing transcriptional repressor -
FE254_RS07285 (FE254_07350) 1601302..1602639 + 1338 WP_024889504.1 MFS transporter -
FE254_RS07290 (FE254_07355) 1602817..1603233 + 417 WP_236621755.1 TIGR03757 family integrating conjugative element protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1577222..1634907 57685


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(39-258)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(23-55)


Sequences

Toxin        


Download         Length: 303 a.a.        Molecular weight: 33896.65 Da        Isoelectric Point: 5.4835

>T125574 WP_024889510.1 NZ_CP040349:c1597995-1597087 [Pseudomonas guguanensis]
MAREPLKNVGASVRARLLQRSRDERTDFQILLTRYALERLLYRLSVSAHRNRFILKGAMLFVTWVEAPFRPTRDLDLLGY
GENSPEAIAEAFRAILAQPVDDDGVAFDVDGLEAAPIREELEYGGVRVRTRATIAGARVPIQVDVGFGDAITPGPIEIDY
PALLDAPAPHLRAYPVETVVAEKFHALASRGIANSRLKDFYDLWVIASTFELERMPLAAAVRQTFERRDTALPQERPTGF
TAAYAETWGGQWQAFLTRERMAAAPGDLATVIADLERFLMPLLEDVEASWRWKPGHGWHEAR

Download         Length: 909 bp

>T125574 NZ_CP040349:c1597995-1597087 [Pseudomonas guguanensis]
ATGGCGCGTGAACCCCTGAAGAATGTCGGCGCATCGGTGCGGGCTCGCCTGCTGCAGCGCTCCCGTGACGAGCGCACCGA
CTTCCAGATCCTGCTGACGCGCTATGCGCTGGAGCGGCTGCTGTACCGGCTGAGCGTGTCCGCCCATCGCAACCGCTTCA
TCCTCAAGGGTGCAATGCTGTTCGTGACCTGGGTGGAAGCGCCGTTCCGTCCGACGCGCGATCTGGACTTGCTCGGCTAT
GGCGAGAACAGTCCCGAGGCAATTGCCGAAGCGTTTCGCGCGATCCTGGCCCAGCCCGTCGATGACGACGGTGTGGCGTT
CGATGTCGATGGGCTCGAAGCCGCGCCGATCCGCGAGGAACTGGAGTACGGCGGCGTGCGGGTTCGCACGCGGGCCACGA
TTGCCGGCGCTCGCGTTCCGATCCAGGTCGATGTGGGTTTCGGCGATGCGATCACGCCCGGGCCGATCGAGATCGACTAC
CCGGCGCTGCTCGATGCGCCGGCGCCGCACCTGCGGGCGTATCCCGTCGAGACAGTGGTGGCGGAGAAGTTTCATGCGCT
CGCGTCGCGCGGCATCGCCAACAGCCGGCTGAAGGATTTCTACGATCTGTGGGTGATCGCCTCGACGTTCGAGCTGGAGC
GGATGCCGCTGGCCGCGGCCGTCCGTCAGACCTTCGAGCGGCGCGACACGGCGCTACCGCAGGAGCGGCCGACCGGGTTC
ACCGCTGCCTACGCCGAGACCTGGGGCGGACAGTGGCAGGCGTTCCTGACCCGCGAGCGGATGGCGGCAGCGCCGGGGGA
CCTGGCAACGGTGATCGCGGACCTGGAGCGCTTCCTGATGCCGCTGCTGGAGGACGTGGAAGCATCCTGGCGCTGGAAGC
CTGGTCATGGGTGGCACGAGGCAAGGTAA

Antitoxin


Download         Length: 207 a.a.        Molecular weight: 22990.45 Da        Isoelectric Point: 10.3629

>AT125574 WP_024889509.1 NZ_CP040349:c1598605-1597985 [Pseudomonas guguanensis]
VANTSTQRDQALKLLGARSTMRQRDFAARGIDPETLARLVREGVVVRPARGLYQLADGPADARRALAEAAALVPKGVVCL
VSALQFHELTLQMPSSVWMAIERTAWRPRIDYPPIRFVRFTGSAMNEGVERHRIEGVDVAITDPARTIVDCFRYREKIGI
DVALEGLREGLRQRKATSDQLWRYGTKARVWSTMKPYVEATVADGA

Download         Length: 621 bp

>AT125574 NZ_CP040349:c1598605-1597985 [Pseudomonas guguanensis]
GTGGCAAACACCAGCACCCAGCGCGACCAGGCGCTCAAGCTCCTGGGCGCCCGTTCCACGATGCGGCAGAGGGACTTCGC
CGCCCGAGGCATCGACCCGGAGACGCTTGCGCGCCTGGTCCGGGAAGGCGTCGTCGTGCGTCCGGCACGGGGGCTGTACC
AGCTGGCCGACGGGCCGGCCGACGCTCGCCGGGCGCTGGCCGAAGCCGCGGCGCTTGTGCCCAAGGGCGTCGTCTGCCTG
GTGTCGGCGCTGCAATTTCACGAACTCACCCTGCAGATGCCGTCGAGCGTGTGGATGGCGATCGAGCGGACCGCCTGGCG
CCCGCGGATCGACTACCCGCCGATCCGGTTCGTGCGCTTCACCGGGTCGGCCATGAACGAGGGGGTCGAACGGCATCGCA
TCGAGGGCGTGGACGTGGCGATCACCGATCCGGCGCGGACCATCGTCGATTGCTTCCGCTATCGCGAGAAGATCGGGATC
GACGTGGCGCTGGAAGGACTGCGCGAGGGCCTGCGGCAGCGCAAGGCGACGAGCGATCAGCTGTGGCGGTACGGGACCAA
GGCCCGGGTCTGGTCGACCATGAAACCCTATGTCGAGGCGACGGTGGCCGATGGCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References