Detailed information of TA system TA125561

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 50163..50688
• Replicon: plasmid p16-6397.1
• Accession: NZ_CP040322
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain PNCS014879

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: E5O16_RS24640
• Protein ID: WP_001159863.1
• Coordinates: 50383..50688 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: E5O16_RS24635
• Protein ID: WP_000813641.1
• Coordinates: 50163..50381 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5O16_RS24605	45450..45831	+	382	Protein_51	YgiW/YdeI family stress tolerance OB fold protein	-
E5O16_RS24610	46000..46444	+	445	Protein_52	site-specific integrase	-
E5O16_RS24615	46703..47692	-	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
E5O16_RS24620	48186..48482	-	297	WP_001687482.1	hypothetical protein	-
E5O16_RS24630	48966..49487	-	522	WP_010999942.1	hypothetical protein	-
E5O16_RS24635	50163..50381	+	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
E5O16_RS24640	50383..50688	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
E5O16_RS24645	50690..50980	+	291	WP_001266176.1	hypothetical protein	-
E5O16_RS24650	50977..51498	+	522	WP_000198608.1	hypothetical protein	-
E5O16_RS24655	51533..52315	+	783	WP_000082169.1	site-specific integrase	-
E5O16_RS24660	52324..53037	+	714	Protein_61	EAL domain-containing protein	-
E5O16_RS24670	53041..53550	+	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
E5O16_RS24675	53544..54029	+	486	WP_000905606.1	membrane protein	-
E5O16_RS24680	54306..54593	-	288	WP_071530243.1	hypothetical protein	-
E5O16_RS24685	54749..55309	+	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93911	93911

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T125561 WP_001159863.1 NZ_CP040322:50383-50688 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T125561 NZ_CP040322:50383-50688 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT125561 WP_000813641.1 NZ_CP040322:50163-50381 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT125561 NZ_CP040322:50163-50381 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6