Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 8904..9429 Replicon plasmid p11-0883.1
Accession NZ_CP040319
Organism Salmonella enterica subsp. enterica serovar Rough O:-:- strain PNCS009887

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag CVI53_RS24300 Protein ID WP_001159871.1
Coordinates 9124..9429 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1PPD8
Locus tag CVI53_RS24295 Protein ID WP_000813634.1
Coordinates 8904..9122 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVI53_RS24260 4235..4525 + 291 WP_000648897.1 hypothetical protein -
CVI53_RS24270 5098..6099 + 1002 WP_000785695.1 DUF4238 domain-containing protein -
CVI53_RS24275 6273..6617 - 345 WP_000792769.1 hypothetical protein -
CVI53_RS24280 7115..7369 - 255 WP_000678528.1 hypothetical protein -
CVI53_RS24285 7419..8345 - 927 WP_001290414.1 hypothetical protein -
CVI53_RS24295 8904..9122 + 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
CVI53_RS24300 9124..9429 + 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
CVI53_RS24305 9430..10239 + 810 WP_000016963.1 site-specific integrase -
CVI53_RS24310 10411..10764 + 354 WP_000864813.1 colicin M immunity protein -
CVI53_RS24315 10814..11383 - 570 Protein_13 lipid II-degrading bacteriocin colicin M -
CVI53_RS24320 11440..12137 + 698 Protein_14 IS1 family transposase -
CVI53_RS24325 12537..13234 + 698 Protein_15 IS1 family transposase -
CVI53_RS24330 13250..13840 - 591 Protein_16 colicin-B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..47477 47477


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)

Antitoxin

Toxin YoeB

(5-84)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T125559 WP_001159871.1 NZ_CP040319:9124-9429 [Salmonella enterica subsp. enterica serovar Rough O:-:-]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T125559 NZ_CP040319:9124-9429 [Salmonella enterica subsp. enterica serovar Rough O:-:-]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT125559 WP_000813634.1 NZ_CP040319:8904-9122 [Salmonella enterica subsp. enterica serovar Rough O:-:-]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT125559 NZ_CP040319:8904-9122 [Salmonella enterica subsp. enterica serovar Rough O:-:-]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
PDB 3TCJ
PDB 2H3A
PDB 2ADN
PDB 2ADL
PDB 3HPW
PDB 2H3C
PDB 3G7Z
AlphaFold DB A0A829CQY2

References