Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1991167..1991645 Replicon chromosome
Accession NZ_CP040316
Organism Escherichia coli strain CV261

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag FEL12_RS09280 Protein ID WP_001303876.1
Coordinates 1991167..1991454 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag FEL12_RS09285 Protein ID WP_000536233.1
Coordinates 1991454..1991645 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEL12_RS09250 1986316..1988787 - 2472 WP_000034474.1 exonuclease -
FEL12_RS09255 1988881..1989072 - 192 WP_001098307.1 DUF1482 family protein -
FEL12_RS09260 1989069..1989257 - 189 WP_000413705.1 cell division inhibition protein DicB -
FEL12_RS09265 1989831..1990016 + 186 WP_001133046.1 hypothetical protein -
FEL12_RS09270 1990203..1990592 - 390 WP_000394511.1 hypothetical protein -
FEL12_RS09275 1990734..1990889 - 156 WP_000379575.1 DUF1391 family protein -
FEL12_RS09280 1991167..1991454 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FEL12_RS09285 1991454..1991645 - 192 WP_000536233.1 hypothetical protein Antitoxin
FEL12_RS09290 1991673..1992074 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
FEL12_RS09295 1992183..1992455 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
FEL12_RS09300 1992439..1992864 + 426 WP_000693855.1 Rha family transcriptional regulator -
FEL12_RS09305 1993071..1993526 - 456 WP_000273724.1 hypothetical protein -
FEL12_RS09310 1993605..1994696 + 1092 WP_001205823.1 hypothetical protein -
FEL12_RS09315 1994703..1995449 + 747 WP_000788751.1 ATP-binding protein -
FEL12_RS09320 1995471..1996241 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T125528 WP_001303876.1 NZ_CP040316:c1991454-1991167 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T125528 NZ_CP040316:c1991454-1991167 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT125528 WP_000536233.1 NZ_CP040316:c1991645-1991454 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT125528 NZ_CP040316:c1991645-1991454 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References