Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1957832..1958310 Replicon chromosome
Accession NZ_CP040314
Organism Escherichia coli strain MA11

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag FEL10_RS09080 Protein ID WP_001303876.1
Coordinates 1957832..1958119 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag FEL10_RS09085 Protein ID WP_000536233.1
Coordinates 1958119..1958310 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEL10_RS09050 1952981..1955452 - 2472 WP_000034474.1 exonuclease -
FEL10_RS09055 1955546..1955737 - 192 WP_001098307.1 DUF1482 family protein -
FEL10_RS09060 1955734..1955922 - 189 WP_000413705.1 cell division inhibition protein DicB -
FEL10_RS09065 1956496..1956681 + 186 WP_001133046.1 hypothetical protein -
FEL10_RS09070 1956868..1957257 - 390 WP_000394511.1 hypothetical protein -
FEL10_RS09075 1957399..1957554 - 156 WP_000379575.1 DUF1391 family protein -
FEL10_RS09080 1957832..1958119 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FEL10_RS09085 1958119..1958310 - 192 WP_000536233.1 hypothetical protein Antitoxin
FEL10_RS09090 1958338..1958739 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
FEL10_RS09095 1958848..1959120 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
FEL10_RS09100 1959104..1959529 + 426 WP_000693855.1 Rha family transcriptional regulator -
FEL10_RS09105 1959736..1960191 - 456 WP_000273724.1 hypothetical protein -
FEL10_RS09110 1960270..1961361 + 1092 WP_001205823.1 hypothetical protein -
FEL10_RS09115 1961368..1962114 + 747 WP_000788751.1 ATP-binding protein -
FEL10_RS09120 1962136..1962906 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T125485 WP_001303876.1 NZ_CP040314:c1958119-1957832 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T125485 NZ_CP040314:c1958119-1957832 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT125485 WP_000536233.1 NZ_CP040314:c1958310-1958119 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT125485 NZ_CP040314:c1958310-1958119 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References