Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1944812..1945290 Replicon chromosome
Accession NZ_CP040309
Organism Escherichia coli strain 21B8

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag FEK99_RS08990 Protein ID WP_001303876.1
Coordinates 1944812..1945099 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag FEK99_RS08995 Protein ID WP_000536233.1
Coordinates 1945099..1945290 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEK99_RS08960 1939961..1942432 - 2472 WP_000034474.1 exonuclease -
FEK99_RS08965 1942526..1942717 - 192 WP_001098307.1 DUF1482 family protein -
FEK99_RS08970 1942714..1942902 - 189 WP_000413705.1 cell division inhibition protein DicB -
FEK99_RS08975 1943476..1943661 + 186 WP_001133046.1 hypothetical protein -
FEK99_RS08980 1943848..1944237 - 390 WP_000394511.1 hypothetical protein -
FEK99_RS08985 1944379..1944534 - 156 WP_000379575.1 DUF1391 family protein -
FEK99_RS08990 1944812..1945099 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FEK99_RS08995 1945099..1945290 - 192 WP_000536233.1 hypothetical protein Antitoxin
FEK99_RS09000 1945318..1945719 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
FEK99_RS09005 1945828..1946100 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
FEK99_RS09010 1946084..1946509 + 426 WP_000693855.1 Rha family transcriptional regulator -
FEK99_RS09015 1946716..1947171 - 456 WP_000273724.1 hypothetical protein -
FEK99_RS09020 1947250..1948341 + 1092 WP_001205823.1 hypothetical protein -
FEK99_RS09025 1948348..1949094 + 747 WP_000788751.1 ATP-binding protein -
FEK99_RS09030 1949116..1949886 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T125361 WP_001303876.1 NZ_CP040309:c1945099-1944812 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T125361 NZ_CP040309:c1945099-1944812 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT125361 WP_000536233.1 NZ_CP040309:c1945290-1945099 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT125361 NZ_CP040309:c1945290-1945099 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References