Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | paaR-paaA-parE/- |
Location | 1944812..1945290 | Replicon | chromosome |
Accession | NZ_CP040309 | ||
Organism | Escherichia coli strain 21B8 |
Toxin (Protein)
Gene name | parE_1 | Uniprot ID | A0A891SFN9 |
Locus tag | FEK99_RS08990 | Protein ID | WP_001303876.1 |
Coordinates | 1944812..1945099 (-) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | paaA | Uniprot ID | Q8XD67 |
Locus tag | FEK99_RS08995 | Protein ID | WP_000536233.1 |
Coordinates | 1945099..1945290 (-) | Length | 64 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FEK99_RS08960 | 1939961..1942432 | - | 2472 | WP_000034474.1 | exonuclease | - |
FEK99_RS08965 | 1942526..1942717 | - | 192 | WP_001098307.1 | DUF1482 family protein | - |
FEK99_RS08970 | 1942714..1942902 | - | 189 | WP_000413705.1 | cell division inhibition protein DicB | - |
FEK99_RS08975 | 1943476..1943661 | + | 186 | WP_001133046.1 | hypothetical protein | - |
FEK99_RS08980 | 1943848..1944237 | - | 390 | WP_000394511.1 | hypothetical protein | - |
FEK99_RS08985 | 1944379..1944534 | - | 156 | WP_000379575.1 | DUF1391 family protein | - |
FEK99_RS08990 | 1944812..1945099 | - | 288 | WP_001303876.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
FEK99_RS08995 | 1945099..1945290 | - | 192 | WP_000536233.1 | hypothetical protein | Antitoxin |
FEK99_RS09000 | 1945318..1945719 | - | 402 | WP_000986592.1 | helix-turn-helix domain-containing protein | - |
FEK99_RS09005 | 1945828..1946100 | + | 273 | WP_000887453.1 | helix-turn-helix domain-containing protein | - |
FEK99_RS09010 | 1946084..1946509 | + | 426 | WP_000693855.1 | Rha family transcriptional regulator | - |
FEK99_RS09015 | 1946716..1947171 | - | 456 | WP_000273724.1 | hypothetical protein | - |
FEK99_RS09020 | 1947250..1948341 | + | 1092 | WP_001205823.1 | hypothetical protein | - |
FEK99_RS09025 | 1948348..1949094 | + | 747 | WP_000788751.1 | ATP-binding protein | - |
FEK99_RS09030 | 1949116..1949886 | + | 771 | WP_000450992.1 | DUF1627 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10978.84 Da Isoelectric Point: 10.1360
>T125361 WP_001303876.1 NZ_CP040309:c1945099-1944812 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI
Download Length: 288 bp
>T125361 NZ_CP040309:c1945099-1944812 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7025.80 Da Isoelectric Point: 4.0270
>AT125361 WP_000536233.1 NZ_CP040309:c1945290-1945099 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE
Download Length: 192 bp
>AT125361 NZ_CP040309:c1945290-1945099 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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