Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 556956..557551 Replicon chromosome
Accession NZ_CP040309
Organism Escherichia coli strain 21B8

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag FEK99_RS02635 Protein ID WP_000239579.1
Coordinates 557201..557551 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID Q8XCF3
Locus tag FEK99_RS02630 Protein ID WP_001223210.1
Coordinates 556956..557207 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEK99_RS02620 552621..556400 + 3780 WP_000060930.1 autotransporter assembly complex protein TamB -
FEK99_RS02625 556403..556744 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
FEK99_RS02630 556956..557207 + 252 WP_001223210.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
FEK99_RS02635 557201..557551 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
FEK99_RS02640 557631..558161 - 531 WP_000055075.1 inorganic diphosphatase -
FEK99_RS02645 558471..559427 + 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
FEK99_RS02650 559567..561069 + 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
FEK99_RS02655 561083..562105 + 1023 WP_001301928.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-114)

Antitoxin

(6-49)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T125351 WP_000239579.1 NZ_CP040309:557201-557551 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T125351 NZ_CP040309:557201-557551 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9299.64 Da        Isoelectric Point: 4.4201

>AT125351 WP_001223210.1 NZ_CP040309:556956-557207 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEVQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT125351 NZ_CP040309:556956-557207 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGTGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8


Antitoxin

Source ID Structure

References