Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1974650..1975128 Replicon chromosome
Accession NZ_CP040305
Organism Escherichia coli strain HB6

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag FEL06_RS09195 Protein ID WP_001303876.1
Coordinates 1974650..1974937 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag FEL06_RS09200 Protein ID WP_000536233.1
Coordinates 1974937..1975128 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEL06_RS09165 1969799..1972270 - 2472 WP_000034474.1 exonuclease -
FEL06_RS09170 1972364..1972555 - 192 WP_001098307.1 DUF1482 family protein -
FEL06_RS09175 1972552..1972740 - 189 WP_000413705.1 cell division inhibition protein DicB -
FEL06_RS09180 1973314..1973499 + 186 WP_001133046.1 hypothetical protein -
FEL06_RS09185 1973686..1974075 - 390 WP_000394511.1 hypothetical protein -
FEL06_RS09190 1974217..1974372 - 156 WP_000379575.1 DUF1391 family protein -
FEL06_RS09195 1974650..1974937 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FEL06_RS09200 1974937..1975128 - 192 WP_000536233.1 hypothetical protein Antitoxin
FEL06_RS09205 1975156..1975557 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
FEL06_RS09210 1975666..1975938 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
FEL06_RS09215 1975922..1976347 + 426 WP_000693855.1 Rha family transcriptional regulator -
FEL06_RS09220 1976554..1977009 - 456 WP_000273724.1 hypothetical protein -
FEL06_RS09225 1977088..1978179 + 1092 WP_001205823.1 hypothetical protein -
FEL06_RS09230 1978186..1978932 + 747 WP_000788751.1 ATP-binding protein -
FEL06_RS09235 1978954..1979724 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T125295 WP_001303876.1 NZ_CP040305:c1974937-1974650 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T125295 NZ_CP040305:c1974937-1974650 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT125295 WP_000536233.1 NZ_CP040305:c1975128-1974937 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT125295 NZ_CP040305:c1975128-1974937 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References