Detailed information of TA system TA125287

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 4828397..4828933
• Replicon: chromosome
• Accession: NZ_CP040297
• Organism: Nostoc sp. TCL26-01

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FD725_RS20855
• Protein ID: WP_179049914.1
• Coordinates: 4828397..4828696 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: FD725_RS20860
• Protein ID: WP_179049915.1
• Coordinates: 4828700..4828933 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD725_RS20835	4823887..4824207	+	321	WP_179051624.1	hypothetical protein	-
FD725_RS20840	4825416..4826654	+	1239	WP_179049911.1	aminoglycoside phosphotransferase family protein	-
FD725_RS20845	4826712..4827800	+	1089	WP_179049912.1	hypothetical protein	-
FD725_RS20850	4827875..4828321	+	447	WP_179049913.1	acyl-CoA thioesterase	-
FD725_RS20855	4828397..4828696	-	300	WP_179049914.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FD725_RS20860	4828700..4828933	-	234	WP_179049915.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
FD725_RS20865	4829108..4830496	-	1389	WP_179049916.1	2-succinylbenzoate--CoA ligase	-
FD725_RS20870	4830481..4831509	-	1029	WP_179051625.1	o-succinylbenzoate synthase	-
FD725_RS20875	4831592..4832497	-	906	WP_179049917.1	2-carboxy-1,4-naphthoquinone phytyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-91)

Antitoxin

• Antitoxin ParD (4-69)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11925.49 Da
• Isoelectric Point: 6.4850

>T125287 WP_179049914.1 NZ_CP040297:c4828696-4828397 [Nostoc sp. TCL26-01]
MSAFRLTELATQDLLSIGRYTQKTWGIEQRNRYLAMLDDCFHLLAQDPHKGRTCDDIRPGYRKYHIGRHLIFYRETDEKI
DIIRILHDRMDVESHFDED

Nucleotide

• Length: 300 bp

>T125287 NZ_CP040297:c4828696-4828397 [Nostoc sp. TCL26-01]
ATGTCAGCATTTCGCCTAACTGAATTAGCCACCCAGGACTTGCTATCAATCGGTCGCTACACACAAAAAACATGGGGAAT
TGAGCAGAGAAACCGTTATCTTGCTATGTTGGACGACTGCTTTCATCTGTTGGCACAAGATCCACACAAGGGACGTACTT
GCGATGATATTCGTCCAGGATATCGTAAATACCACATCGGACGACACTTGATCTTTTATCGGGAAACCGATGAAAAGATT
GATATTATTCGTATTCTACATGATCGTATGGATGTAGAGTCTCATTTCGATGAAGACTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8514.49 Da
• Isoelectric Point: 4.4488

>AT125287 WP_179049915.1 NZ_CP040297:c4828933-4828700 [Nostoc sp. TCL26-01]
MQKNTSVTLGDHFEAFIASQIDRGRFASASEAIRAGLRLLEEREIKLAALQRALTDGENSEFADYSLSGLLAELDRE

Nucleotide

• Length: 234 bp

>AT125287 NZ_CP040297:c4828933-4828700 [Nostoc sp. TCL26-01]
ATGCAAAAAAATACAAGTGTTACCTTGGGTGACCATTTTGAAGCGTTTATTGCCAGTCAGATTGACAGAGGTCGTTTTGC
CAGCGCGAGTGAAGCGATTCGAGCTGGATTACGCCTTTTGGAAGAGCGAGAAATAAAGCTTGCAGCTTTGCAACGAGCGT
TAACAGACGGAGAGAACAGCGAATTTGCTGACTATTCTCTCTCAGGATTGCTTGCAGAACTTGACCGTGAATAG