Detailed information of TA system TA125286

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 3999108..3999703
• Replicon: chromosome
• Accession: NZ_CP040297
• Organism: Nostoc sp. TCL26-01

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: FD725_RS17435
• Protein ID: WP_179049307.1
• Coordinates: 3999108..3999464 (-)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: FD725_RS17440
• Protein ID: WP_179049308.1
• Coordinates: 3999464..3999703 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD725_RS17385	3994403..3994642	-	240	WP_179049299.1	CopG family transcriptional regulator	-
FD725_RS17390	3994632..3994832	-	201	WP_179049300.1	BrnT family toxin	-
FD725_RS17395	3994917..3995522	-	606	WP_179049301.1	hypothetical protein	-
FD725_RS17400	3995696..3995929	-	234	WP_179049302.1	hypothetical protein	-
FD725_RS17405	3996383..3996985	+	603	WP_179049303.1	hypothetical protein	-
FD725_RS17410	3997137..3997376	+	240	Protein_3420	hypothetical protein	-
FD725_RS17415	3997621..3998004	-	384	WP_179049304.1	hypothetical protein	-
FD725_RS17420	3998132..3998320	+	189	WP_179049305.1	hypothetical protein	-
FD725_RS17425	3998321..3998569	+	249	Protein_3423	BrnT family toxin	-
FD725_RS17430	3998566..3998775	+	210	WP_179049306.1	BrnA antitoxin family protein	-
FD725_RS17435	3999108..3999464	-	357	WP_179049307.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FD725_RS17440	3999464..3999703	-	240	WP_179049308.1	CopG family transcriptional regulator	Antitoxin
FD725_RS17445	3999846..4000139	+	294	Protein_3427	BrnT family toxin	-
FD725_RS17450	4000087..4000362	+	276	WP_179049309.1	BrnA antitoxin family protein	-
FD725_RS17455	4000505..4000903	+	399	WP_179049310.1	hypothetical protein	-
FD725_RS17460	4000973..4001461	+	489	WP_179049311.1	type II toxin-antitoxin system VapC family toxin	-
FD725_RS17465	4001445..4001636	+	192	WP_179049312.1	hypothetical protein	-
FD725_RS17470	4001895..4002368	+	474	WP_179049313.1	hypothetical protein	-
FD725_RS17475	4002635..4004023	-	1389	WP_179049314.1	nitrogenase molybdenum-iron protein alpha chain	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (7-116)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13422.45 Da
• Isoelectric Point: 7.9847

>T125286 WP_179049307.1 NZ_CP040297:c3999464-3999108 [Nostoc sp. TCL26-01]
MPNSVLTYRRGEIRWVTLDPTVGAEVQKTRSCLIVQNDVMNQYGSLTIVMPFRPGTKKAPYVVNVKATTNNGLDQNRYID
VAQIRSVDHSRILGLIGILEDEYWEKIRAALDIVLNFE

Nucleotide

• Length: 357 bp

>T125286 NZ_CP040297:c3999464-3999108 [Nostoc sp. TCL26-01]
ATGCCAAACAGTGTTTTAACTTATCGACGAGGGGAAATTCGCTGGGTAACACTCGATCCAACTGTGGGTGCAGAAGTTCA
AAAAACACGTTCTTGCCTGATAGTGCAGAATGATGTGATGAATCAATATGGTTCTTTAACTATAGTGATGCCATTTCGAC
CGGGAACGAAAAAAGCTCCTTATGTAGTGAATGTCAAAGCTACAACAAACAATGGTTTAGACCAAAACCGCTATATTGAT
GTTGCACAAATTCGTAGTGTTGATCATAGTCGAATATTGGGGTTAATAGGAATTTTGGAAGATGAATATTGGGAGAAAAT
TCGTGCTGCACTAGATATAGTTTTGAATTTTGAATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8700.71 Da
• Isoelectric Point: 3.9840

>AT125286 WP_179049308.1 NZ_CP040297:c3999703-3999464 [Nostoc sp. TCL26-01]
MAKKVTITLDDEILAFIDRQAALAGDTPNRSGYVNAVLAEHRRAILEAEMIAALKEDNENPEYQAEIADWDTIVGDGIE

Nucleotide

• Length: 240 bp

>AT125286 NZ_CP040297:c3999703-3999464 [Nostoc sp. TCL26-01]
TTGGCTAAAAAAGTTACTATTACCCTTGATGATGAGATTCTAGCTTTTATCGACCGACAGGCTGCGTTAGCTGGAGATAC
TCCCAACCGCAGTGGCTATGTCAATGCTGTTTTAGCAGAACATCGTCGCGCGATTTTAGAAGCAGAAATGATTGCAGCAC
TCAAAGAAGATAATGAAAATCCTGAATATCAAGCAGAAATAGCAGATTGGGATACCATTGTGGGAGATGGTATTGAATAA