Detailed information of TA system TA125285

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 3994403..3994832
• Replicon: chromosome
• Accession: NZ_CP040297
• Organism: Nostoc sp. TCL26-01

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FD725_RS17390
• Protein ID: WP_179049300.1
• Coordinates: 3994632..3994832 (-)
• Length: 67 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FD725_RS17385
• Protein ID: WP_179049299.1
• Coordinates: 3994403..3994642 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD725_RS17375	3990085..3990699	+	615	WP_179049297.1	GNAT family N-acetyltransferase	-
FD725_RS17380	3990796..3994377	+	3582	WP_179049298.1	pentapeptide repeat-containing protein	-
FD725_RS17385	3994403..3994642	-	240	WP_179049299.1	CopG family transcriptional regulator	Antitoxin
FD725_RS17390	3994632..3994832	-	201	WP_179049300.1	BrnT family toxin	Toxin
FD725_RS17395	3994917..3995522	-	606	WP_179049301.1	hypothetical protein	-
FD725_RS17400	3995696..3995929	-	234	WP_179049302.1	hypothetical protein	-
FD725_RS17405	3996383..3996985	+	603	WP_179049303.1	hypothetical protein	-
FD725_RS17410	3997137..3997376	+	240	Protein_3420	hypothetical protein	-
FD725_RS17415	3997621..3998004	-	384	WP_179049304.1	hypothetical protein	-
FD725_RS17420	3998132..3998320	+	189	WP_179049305.1	hypothetical protein	-
FD725_RS17425	3998321..3998569	+	249	Protein_3423	BrnT family toxin	-
FD725_RS17430	3998566..3998775	+	210	WP_179049306.1	BrnA antitoxin family protein	-
FD725_RS17435	3999108..3999464	-	357	WP_179049307.1	type II toxin-antitoxin system PemK/MazF family toxin	-
FD725_RS17440	3999464..3999703	-	240	WP_179049308.1	CopG family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (7-60)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 67 a.a.
• Molecular weight: 7700.84 Da
• Isoelectric Point: 8.5375

>T125285 WP_179049300.1 NZ_CP040297:c3994832-3994632 [Nostoc sp. TCL26-01]
MSIDISHNKTYLTLSTDPKAIDEPRFLVIGLINGKHWSAVITYREERVRIISVRRARDEEVKIYEG

Nucleotide

• Length: 201 bp

>T125285 NZ_CP040297:c3994832-3994632 [Nostoc sp. TCL26-01]
TTGTCGATAGACATCTCCCACAACAAAACCTACCTTACACTATCCACAGATCCCAAAGCCATTGATGAACCAAGGTTTCT
CGTAATTGGACTAATAAATGGGAAGCATTGGTCTGCCGTCATCACATACAGAGAAGAGCGGGTGCGAATCATATCAGTCA
GGCGAGCAAGAGATGAAGAGGTAAAAATATATGAAGGCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9337.54 Da
• Isoelectric Point: 4.6794

>AT125285 WP_179049299.1 NZ_CP040297:c3994642-3994403 [Nostoc sp. TCL26-01]
MKAEEFDEKFDSGEDITSYLDLSTIRRPGYEQRRVNVDFPLWVIEALDKEAERIGVTRQSIIKVWIAERLEQHSQVKNL

Nucleotide

• Length: 240 bp

>AT125285 NZ_CP040297:c3994642-3994403 [Nostoc sp. TCL26-01]
ATGAAGGCTGAAGAATTTGATGAAAAATTTGACTCTGGAGAGGATATTACCTCTTACTTAGACCTTTCTACAATTCGTCG
TCCTGGCTACGAGCAGCGACGAGTAAATGTTGATTTTCCCTTATGGGTAATTGAAGCGCTTGATAAGGAAGCAGAGCGAA
TTGGTGTAACCCGACAATCAATTATAAAAGTATGGATTGCCGAGCGACTTGAACAGCATAGTCAAGTCAAAAATCTCTGA