Detailed information of TA system TA125281

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 140701..141472
• Replicon: chromosome
• Accession: NZ_CP040297
• Organism: Nostoc sp. TCL26-01

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FD725_RS00585
• Protein ID: WP_179046335.1
• Coordinates: 140701..141198 (-)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FD725_RS00590
• Protein ID: WP_179046336.1
• Coordinates: 141185..141472 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD725_RS00565	135752..136684	-	933	WP_179046332.1	phosphodiester glycosidase family protein	-
FD725_RS00570	137554..138939	+	1386	WP_179051370.1	PP2C family protein-serine/threonine phosphatase	-
FD725_RS00575	139072..139974	+	903	WP_179046333.1	ABC transporter permease	-
FD725_RS00580	140145..140522	+	378	WP_179046334.1	PEP-CTERM sorting domain-containing protein	-
FD725_RS00585	140701..141198	-	498	WP_179046335.1	GNAT family N-acetyltransferase	Toxin
FD725_RS00590	141185..141472	-	288	WP_179046336.1	DUF1778 domain-containing protein	Antitoxin
FD725_RS00595	141626..142444	+	819	WP_179046337.1	DUF3598 family protein	-
FD725_RS00600	142561..142959	+	399	WP_179046338.1	hypothetical protein	-
FD725_RS00605	143073..144182	+	1110	WP_179046339.1	EndoU domain-containing protein	-
FD725_RS00610	144510..145175	+	666	WP_179046340.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-148)

Antitoxin

• Vibrio phage ICP1, Orf50 (4-90)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18731.75 Da
• Isoelectric Point: 6.4742

>T125281 WP_179046335.1 NZ_CP040297:c141198-140701 [Nostoc sp. TCL26-01]
VRAIELLGKQHDRDRFDCGNEVLNLFLKQIARQHIQKGVSRTFVLVDTEQPDIIIAFFTLTLCEVRVDKFSAKFFKKYPD
KIPGVKLARLAVDQAYQRQGIGEVLMIEAMQRALIVAENAGGIGLFVDAKDESAKTYYSRYGFVSLEDTSLELFLPLSVI
QQMLE

Nucleotide

• Length: 498 bp

>T125281 NZ_CP040297:c141198-140701 [Nostoc sp. TCL26-01]
GTGAGAGCTATTGAATTGCTGGGTAAGCAACATGACCGAGATCGCTTTGATTGTGGCAATGAAGTATTAAATCTATTCCT
TAAACAAATAGCAAGACAACATATCCAAAAAGGTGTTTCCCGTACTTTCGTTTTAGTTGATACAGAACAGCCAGATATCA
TAATTGCTTTTTTTACATTGACATTGTGTGAGGTGCGTGTAGACAAATTTTCAGCGAAATTCTTCAAGAAATACCCTGAT
AAAATTCCTGGTGTAAAGCTAGCAAGATTAGCAGTTGATCAAGCTTATCAGAGGCAAGGAATTGGAGAAGTTTTGATGAT
TGAGGCAATGCAGCGTGCTTTAATTGTTGCAGAAAATGCAGGAGGAATTGGCTTATTTGTTGATGCAAAAGATGAAAGTG
CCAAAACTTATTACTCTCGCTATGGTTTCGTCAGTCTTGAAGATACATCTTTGGAACTTTTTTTGCCATTGTCTGTAATT
CAGCAAATGCTTGAGTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10637.25 Da
• Isoelectric Point: 5.7083

>AT125281 WP_179046336.1 NZ_CP040297:c141472-141185 [Nostoc sp. TCL26-01]
MSNSHENTVRITARIPVNIQETLKIAAELSGATLNQFMIQAALKEAKKVIEDERVILLSQNDADLVFSLIENPPVLNAEL
KAALKKHKEFFSESY

Nucleotide

• Length: 288 bp

>AT125281 NZ_CP040297:c141472-141185 [Nostoc sp. TCL26-01]
ATGTCTAACAGTCACGAAAATACCGTTCGGATAACTGCCAGAATTCCTGTCAATATTCAAGAAACTCTAAAAATAGCGGC
AGAATTATCGGGTGCTACCTTGAATCAATTTATGATTCAAGCGGCGTTGAAAGAAGCAAAAAAAGTGATAGAAGATGAAC
GAGTAATTCTTTTGTCACAAAATGATGCTGATCTAGTATTTAGCCTAATTGAAAATCCTCCTGTACTGAATGCAGAATTA
AAAGCAGCCTTGAAAAAGCACAAGGAATTTTTCAGTGAGAGCTATTGA