Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 6738252..6738847 Replicon chromosome
Accession NZ_CP040281
Organism Nostoc sp. C057

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FD724_RS28730 Protein ID WP_174711983.1
Coordinates 6738252..6738512 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FD724_RS28735 Protein ID WP_069068732.1
Coordinates 6738509..6738847 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD724_RS28695 6735028..6735603 + 576 WP_179074945.1 Uma2 family endonuclease -
FD724_RS28700 6735625..6736632 + 1008 WP_179074946.1 hypothetical protein -
FD724_RS28705 6736903..6737100 + 198 WP_179075657.1 hypothetical protein -
FD724_RS28710 6737084..6737413 + 330 WP_179074947.1 type II toxin-antitoxin system PemK/MazF family toxin -
FD724_RS28715 6737480..6737698 + 219 Protein_5654 addiction module protein -
FD724_RS28720 6737713..6737983 + 271 Protein_5655 type II toxin-antitoxin system RelE/ParE family toxin -
FD724_RS28725 6738043..6738195 - 153 WP_179074948.1 hypothetical protein -
FD724_RS28730 6738252..6738512 + 261 WP_174711983.1 type II toxin-antitoxin system HicA family toxin Toxin
FD724_RS28735 6738509..6738847 + 339 WP_069068732.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FD724_RS28740 6738984..6739199 - 216 Protein_5659 hypothetical protein -
FD724_RS28745 6739407..6740321 - 915 WP_179074949.1 VOC family protein -
FD724_RS28750 6740366..6741685 - 1320 WP_179074950.1 acetyl ornithine aminotransferase family protein -
FD724_RS28755 6742010..6742339 + 330 WP_179074951.1 hypothetical protein -
FD724_RS28760 6742543..6743760 - 1218 WP_179074952.1 amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-84)

Antitoxin

Uncharacterised protein family HicB

(52-102)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9722.23 Da        Isoelectric Point: 8.7566

>T125280 WP_174711983.1 NZ_CP040281:6738252-6738512 [Nostoc sp. C057]
MDLNNKQRQILELIFTNPVPSNILWKDIESLFIALGADITQGRGSRVRVKLNDVKAVFHEPHPQNETDKGAVKSVREFLI
KAGIEI

Download         Length: 261 bp

>T125280 NZ_CP040281:6738252-6738512 [Nostoc sp. C057]
ATGGATCTCAATAACAAACAACGTCAGATTTTAGAGTTAATTTTTACAAATCCTGTACCATCTAATATTCTTTGGAAAGA
TATTGAAAGTTTATTTATAGCTCTCGGTGCTGATATTACTCAAGGTAGAGGTTCGCGGGTTCGTGTGAAATTAAATGATG
TGAAAGCTGTTTTTCACGAACCGCATCCTCAAAATGAGACAGATAAAGGAGCAGTCAAATCTGTTAGAGAATTTTTAATT
AAGGCAGGAATTGAAATATGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12530.28 Da        Isoelectric Point: 4.5951

>AT125280 WP_069068732.1 NZ_CP040281:6738509-6738847 [Nostoc sp. C057]
MMTYKGYTASIEVDVEAGILFGQVLDINDVITFKAKTVDEARQEFQISVDDYLAFCEELGEEPDKPFSGKLPFRTTPEHH
RKIFIAAKKAGKSINAWMDEILTGAADKVINT

Download         Length: 339 bp

>AT125280 NZ_CP040281:6738509-6738847 [Nostoc sp. C057]
ATGATGACTTATAAAGGATACACAGCTAGTATAGAAGTAGATGTAGAAGCGGGAATACTTTTTGGCCAAGTCCTAGATAT
TAATGATGTAATTACCTTTAAGGCAAAAACTGTAGACGAAGCGCGTCAAGAATTTCAAATTTCTGTTGATGATTATCTTG
CTTTCTGTGAAGAATTAGGAGAGGAGCCTGATAAACCATTCTCTGGTAAACTTCCATTCCGCACAACTCCAGAACACCAC
CGCAAAATATTTATTGCTGCTAAAAAGGCTGGCAAAAGCATAAATGCTTGGATGGATGAAATATTAACTGGTGCTGCGGA
TAAAGTAATCAATACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References