Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 7175424..7176037 Replicon chromosome
Accession NZ_CP040272
Organism Nostoc sp. C052

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FD723_RS29645 Protein ID WP_179068543.1
Coordinates 7175424..7175810 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FD723_RS29650 Protein ID WP_179068544.1
Coordinates 7175807..7176037 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FD723_RS29615 7171133..7171588 - 456 WP_179068538.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
FD723_RS29620 7171599..7173008 - 1410 WP_179068539.1 YvcK family protein -
FD723_RS29625 7173263..7173754 + 492 WP_179068540.1 crossover junction endodeoxyribonuclease RuvC -
FD723_RS29630 7173898..7174254 + 357 WP_179065332.1 IS630 transposase-related protein -
FD723_RS29635 7174290..7174640 + 351 WP_179068541.1 transposase -
FD723_RS29640 7174668..7175353 + 686 WP_179068542.1 IS1 family transposase -
FD723_RS29645 7175424..7175810 - 387 WP_179068543.1 type II toxin-antitoxin system VapC family toxin Toxin
FD723_RS29650 7175807..7176037 - 231 WP_179068544.1 DUF2281 domain-containing protein Antitoxin
FD723_RS29655 7176558..7177118 - 561 WP_179068545.1 Uma2 family endonuclease -
FD723_RS29660 7177260..7177760 - 501 WP_179068546.1 hypothetical protein -
FD723_RS29665 7177808..7178095 - 288 WP_179068547.1 hypothetical protein -
FD723_RS29670 7178448..7180445 - 1998 WP_179069323.1 excinuclease ABC subunit UvrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-127)

Antitoxin

Domain of unknown function DUF2281

(6-74)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14499.63 Da        Isoelectric Point: 6.0668

>T125273 WP_179068543.1 NZ_CP040272:c7175810-7175424 [Nostoc sp. C052]
MSGFLLDTHAFIWLTENNSSLPDNLRRSINTADTVYLSIASLWEIAIKLNLGKLSLQRSYETIGSAIDASDILILPISFA
DTVQVRNLPLHHGDPFDRMLIAQAINHSLIIISRDKKFDAYSVQRMWE

Download         Length: 387 bp

>T125273 NZ_CP040272:c7175810-7175424 [Nostoc sp. C052]
ATGAGTGGTTTCCTTTTAGATACTCATGCTTTTATCTGGCTAACTGAAAATAACTCCAGCCTTCCAGATAATCTCAGGAG
ATCGATCAATACGGCAGATACCGTTTATCTCAGTATCGCTAGTCTTTGGGAAATTGCCATCAAGTTGAACCTTGGTAAAT
TATCGCTTCAACGGAGCTATGAAACGATAGGTTCTGCGATCGACGCTTCAGATATTCTCATACTTCCGATATCTTTTGCC
GATACAGTTCAAGTTCGGAATCTCCCGCTACATCATGGCGATCCATTTGACAGAATGTTGATTGCACAGGCTATCAATCA
CTCCTTAATTATTATTAGCAGGGATAAAAAATTCGATGCTTATTCTGTTCAAAGGATGTGGGAATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8902.20 Da        Isoelectric Point: 4.3219

>AT125273 WP_179068544.1 NZ_CP040272:c7176037-7175807 [Nostoc sp. C052]
MAIDAEILQTLNQMPEPLKQELLHYAKYLVENYSKTVAQESLQQKKRRSGILEGTFVLPLPDDFDEPLEVFKEYME

Download         Length: 231 bp

>AT125273 NZ_CP040272:c7176037-7175807 [Nostoc sp. C052]
ATGGCTATTGATGCAGAAATTTTACAAACACTAAATCAAATGCCAGAGCCACTTAAACAAGAACTCTTGCATTATGCAAA
ATATTTAGTTGAGAATTATTCAAAAACTGTTGCTCAAGAAAGTTTACAACAAAAAAAGCGTCGTTCTGGCATCTTAGAAG
GGACTTTTGTTTTACCTTTACCTGATGACTTTGATGAACCTCTCGAAGTTTTTAAGGAATATATGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References