Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2689391..2690029 Replicon chromosome
Accession NZ_CP040263
Organism Escherichia coli strain 631

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag EST51_RS13305 Protein ID WP_000813795.1
Coordinates 2689853..2690029 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EST51_RS13300 Protein ID WP_076797675.1
Coordinates 2689391..2689807 (-) Length 139 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EST51_RS13280 2684543..2685484 - 942 WP_106106616.1 ABC transporter permease -
EST51_RS13285 2685485..2686498 - 1014 WP_001551095.1 ABC transporter ATP-binding protein -
EST51_RS13290 2686516..2687661 - 1146 WP_001551094.1 ABC transporter substrate-binding protein -
EST51_RS13295 2687906..2689312 - 1407 WP_001551093.1 PLP-dependent aminotransferase family protein -
EST51_RS13300 2689391..2689807 - 417 WP_076797675.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
EST51_RS13305 2689853..2690029 - 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
EST51_RS13310 2690251..2690481 + 231 WP_023910283.1 YncJ family protein -
EST51_RS13315 2690573..2692534 - 1962 WP_001551090.1 23S rRNA 5-hydroxycytidine C2501 synthase -
EST51_RS13320 2692607..2693143 - 537 WP_001551089.1 DNA-binding transcriptional regulator SutR -
EST51_RS13325 2693196..2694407 + 1212 WP_071591517.1 BenE family transporter YdcO -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T125231 WP_000813795.1 NZ_CP040263:c2690029-2689853 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T125231 NZ_CP040263:c2690029-2689853 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15220.55 Da        Isoelectric Point: 4.7386

>AT125231 WP_076797675.1 NZ_CP040263:c2689807-2689391 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT125231 NZ_CP040263:c2689807-2689391 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATCAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1


Antitoxin

Source ID Structure

References