125213

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 2461..3049 Replicon plasmid unnamed2
Accession NZ_CP040261
Organism Acinetobacter baumannii strain P7774

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag FED54_RS21290 Protein ID WP_000438826.1
Coordinates 2461..2748 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID A0A858UV00
Locus tag FED54_RS21295 Protein ID WP_061855757.1
Coordinates 2735..3049 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FED54_RS21275 1..951 + 951 WP_001205343.1 replication initiation protein RepM -
FED54_RS21280 944..1519 + 576 WP_001096616.1 helix-turn-helix domain-containing protein -
FED54_RS21585 1539..1682 + 144 WP_001125244.1 hypothetical protein -
FED54_RS21290 2461..2748 + 288 WP_000438826.1 BrnT family toxin Toxin
FED54_RS21295 2735..3049 + 315 WP_061855757.1 BrnA antitoxin family protein Antitoxin
FED54_RS21300 3178..5589 + 2412 WP_137987739.1 TonB-dependent receptor ZnuD2 -
FED54_RS21305 5894..6355 + 462 WP_000761346.1 DIP1984 family protein -
FED54_RS21310 6712..7877 - 1166 Protein_7 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..14880 14880


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T125213 WP_000438826.1 NZ_CP040261:2461-2748 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T125213 NZ_CP040261:2461-2748 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12227.88 Da        Isoelectric Point: 8.4628

>AT125213 WP_061855757.1 NZ_CP040261:2735-3049 [Acinetobacter baumannii]
MSMVRYSRKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT125213 NZ_CP040261:2735-3049 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACGCAAAGAGCTAAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB A0A858UV00

References