Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3796606..3797263 Replicon chromosome
Accession NZ_CP040256
Organism Enterobacter ludwigii strain JP6

Toxin (Protein)


Gene name cptA Uniprot ID G8LDB6
Locus tag ELJP6_RS17910 Protein ID WP_014171514.1
Coordinates 3796606..3797016 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag ELJP6_RS17915 Protein ID WP_003863437.1
Coordinates 3796997..3797263 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELJP6_RS17890 3792604..3794337 - 1734 WP_014171509.1 single-stranded-DNA-specific exonuclease RecJ -
ELJP6_RS17895 3794343..3795056 - 714 WP_020883731.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ELJP6_RS17900 3795080..3795976 - 897 WP_014171511.1 site-specific tyrosine recombinase XerD -
ELJP6_RS17905 3796078..3796599 + 522 WP_014171513.1 flavodoxin FldB -
ELJP6_RS17910 3796606..3797016 - 411 WP_014171514.1 protein YgfX Toxin
ELJP6_RS17915 3796997..3797263 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
ELJP6_RS17920 3797558..3798538 + 981 WP_020883730.1 tRNA-modifying protein YgfZ -
ELJP6_RS17925 3798649..3799308 - 660 WP_014171517.1 hemolysin III family protein -
ELJP6_RS17930 3799575..3800306 + 732 WP_086532136.1 MurR/RpiR family transcriptional regulator -
ELJP6_RS17935 3800423..3801856 + 1434 WP_032678925.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16217.15 Da        Isoelectric Point: 11.5020

>T125209 WP_014171514.1 NZ_CP040256:c3797016-3796606 [Enterobacter ludwigii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRIHARQGEIKLLMDSRLRWQGK
EWEILGMPWMIASGMMLRLRSVDSGRRQHLWLAADSMDSAEWRDLRRMLLQQLTQE

Download         Length: 411 bp

>T125209 NZ_CP040256:c3797016-3796606 [Enterobacter ludwigii]
GTGGTCCTGTGGCAATCTGACCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTGTTGCTCCACGGCCTGGTCGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTTAGCTATACGCCTCTGTGGCTGCTGTTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGCCGCATTCATGCCCGTCAGGGGGAGATCAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATTCTCGGTATGCCCTGGATGATCGCTTCCGGCATGATGCTGCGGCTACGTAGCGTGGACAGCGGGCGTCG
CCAGCATCTGTGGCTGGCCGCGGACAGTATGGATAGCGCTGAGTGGCGGGACCTGCGTCGGATGTTATTACAGCAGCTGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT125209 WP_003863437.1 NZ_CP040256:c3797263-3796997 [Enterobacter ludwigii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT125209 NZ_CP040256:c3797263-3796997 [Enterobacter ludwigii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCTGATT
TATTTAACTGGCTGATGAATCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BUV6

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References